Vesicle-associated membrane protein

Vesicle-associated membrane protein

Vesicle associated membrane protein (VAMP) family of proteins includes proteins with similar structure.

* VAMP1 and VAMP2 proteins known as synaptobrevins are expressed in brain and are constituents of the synaptic vesicles, where they participate in neuromediator release.

* VAMP3 (known as cellubrevin) is ubiquitously expressed and participates in regulated and constitutive exocytosis as a constituent of secretory granules and secretory vesicles.

* VAMP5 and VAMP7 (SYBL1) participate in constitutive exocytosis.
** VAMP5 is a constituent of secretory vesicles, myotubes and tubulovesicular structures.
** VAMP7 is found both in secretory granules and endosomes.

* VAMP8 (known as endobrevin) participates in endocytosis and is found in early endosomes. VAMP8 also participates the regulated exocytosis in pancreatic acinar cells.

*VAMP4 is involved in transport from the Golgi. [cite journal |author=Steegmaier M, Klumperman J, Foletti DL, Yoo JS, Scheller RH |title=Vesicle-associated membrane protein 4 is implicated in trans-Golgi network vesicle trafficking |journal=Mol. Biol. Cell |volume=10 |issue=6 |pages=1957–72 |year=1999 |pmid=10359608 |doi=]

References

External links

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[Category:Proteins


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