Synaptobrevin

Synaptobrevin

Synaptobrevins ("synaptobrevin isotypes 1-2") are small integral membrane proteins of secretory vesicles with molecular weight of 18 kilodalton (kDa) that are part of the vesicle-associated membrane protein (VAMP) family.cite journal
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url = http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=2498078
title = Synaptobrevin: an integral membrane protein of 18,000 daltons present in small synaptic vesicles of rat brain
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author = Ernst JA, Brunger AT
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doi = 10.1016/S0092-8674(00)81404-X
title = SNAREpins: minimal machinery for membrane fusion
journal = Cell
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Synaptobrevin is one of the SNARE proteins involved in formation of the SNARE complexes.

tructure

Out of four α-helices of the core SNARE complex one is contributed by synaptobrevin, one by syntaxin, and two by SNAP-25 (in neurons).

Function

SNARE proteins are the key components of the molecular machinery that drives fusion of membranes in exocytosis. Their function however is subject to fine tuning by various regulatory protein collectively referred to as "SNARE masters".

Classification

Because all proteins belonging to VAMP/synaptobrevin family share common structural feature, they have been classified as R-SNAREs. An alternative classification (v- and t-SNAREs) exists that takes into account origin of synaptobrevin-bearing organelle rather than their structural properties.

Clinical significance

Synaptobrevin is degraded by "Tetanospasmin", a protein derived from "Clostridium tetani".

References and notes

External links

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