6C RNA

6C RNA

6C RNA is a class of non-coding RNA present in actinomycetes. 6C RNA was originally discovered as a conserved RNA structure having two stem-loops each containing six or more cytosine residues (which are typically abbreviated using the letter C). [cite journal |author=Weinberg Z, Barrick JE, Yao Z, "et al" |title=Identification of 22 candidate structured RNAs in bacteria using the CMfinder comparative genomics pipeline |journal=Nucleic Acids Res. |volume=35 |issue=14 |pages=4809–19 |year=2007 |pmid=17621584 |pmc=1950547 |doi=10.1093/nar/gkm487 |url=] Later work revealed that 6C RNAs in Streptomyces coelicolor and Streptomyces avermitilis have predicted rho-independent transcription terminators, and microarray and reverse-transcriptase PCR experiments indicate that the "S. coelicolor" version is transcribed as RNA. [cite journal |author=Pánek J, Bobek J, Mikulík K, Basler M, Vohradský J |title=Biocomputational prediction of small non-coding RNAs in Streptomyces |journal=BMC Genomics |volume=9 |issue= |pages=217 |year=2008 |pmid=18477385 |pmc=2422843 |doi=10.1186/1471-2164-9-217 |url=]

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