OSR2 (gene)

Odd-skipped related 2 (Drosophila)
Identifiers
Symbols	OSR2; FLJ90037
External IDs	OMIM: 611297 MGI: 1930813 HomoloGene: 14200 GeneCards: OSR2 Gene
Gene Ontology Molecular function • nucleic acid binding • zinc ion binding • sequence-specific DNA binding • metal ion binding Cellular component • intracellular • nucleus Biological process • negative regulation of transcription from RNA polymerase II promoter • metanephros development • mesonephros development • chondrocyte differentiation • positive regulation of cell proliferation • embryo development • positive regulation of gene expression • cell differentiation • positive regulation of bone mineralization • osteoblast proliferation • embryonic forelimb morphogenesis • embryonic hindlimb morphogenesis • middle ear morphogenesis • odontogenesis • embryonic digit morphogenesis • positive regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • embryonic leg joint morphogenesis • embryonic skeletal system morphogenesis • positive regulation of epithelial cell proliferation • palate development • embryonic skeletal joint morphogenesis • head development • bone morphogenesis • eyelid development in camera-type eye • embryonic skeletal joint development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	116039	107587
Ensembl	ENSG00000164920	ENSMUSG00000022330
UniProt	Q8N2R0	Q91ZD1
RefSeq (mRNA)	NM_001142462.1	NM_054049.2
RefSeq (protein)	NP_001135934.1	NP_473390.1
Location (UCSC)	Chr 8: 99.96 – 99.96 Mb	Chr 15: 35.23 – 35.23 Mb
PubMed search	[1]	[2]

Protein odd-skipped-related 2 is a protein that in humans is encoded by the OSR2 gene.^[1] In mice, it is involved in the development of the palate and in suppressing the formation of teeth after the eruption of adult teeth.

References

1. ^ "Entrez Gene: OSR2 odd-skipped related 2 (Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=116039. 

Further reading

• Kawai S, Kato T, Inaba H et al. (2005). "Odd-skipped related 2 splicing variants show opposite transcriptional activity". Biochem. Biophys. Res. Commun. 328 (1): 306–11. doi:10.1016/j.bbrc.2004.12.173. PMID 15670784. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Lan Y, Ovitt CE, Cho ES et al. (2004). "Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of secondary palate growth and morphogenesis". Development 131 (13): 3207–16. doi:10.1242/dev.01175. PMID 15175245. 
• Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Katoh M (2003). "Molecular cloning and characterization of OSR1 on human chromosome 2p24". Int. J. Mol. Med. 10 (2): 221–5. PMID 12119563. 
• Lan Y, Kingsley PD, Cho ES, Jiang R (2001). "Osr2, a new mouse gene related to Drosophila odd-skipped, exhibits dynamic expression patterns during craniofacial, limb, and kidney development". Mech. Dev. 107 (1–2): 175–9. doi:10.1016/S0925-4773(01)00457-9. PMID 11520675.