CBX2 (gene)

Chromobox homolog 2
PDB rendering based on 2d9u.
Available structures PDB 2D9U, 3H91
Identifiers
Symbols	CBX2; CDCA6; M33; MGC10561
External IDs	OMIM: 602770 MGI: 88289 HomoloGene: 7256 GeneCards: CBX2 Gene
Gene Ontology Molecular function • DNA binding • chromatin binding • protein binding • methylated histone residue binding Cellular component • heterochromatin • nucleus • nucleus • PcG protein complex Biological process • negative regulation of transcription from RNA polymerase II promoter • chromatin modification • cell differentiation • development of primary sexual characteristics • negative regulation of transcription, DNA-dependent Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	84733	12416
Ensembl	ENSG00000173894	ENSMUSG00000025577
UniProt	Q14781	Q3TZG6
RefSeq (mRNA)	NM_005189.2	NM_007623.2
RefSeq (protein)	NP_005180.1	NP_031649.2
Location (UCSC)	Chr 17: 77.75 – 77.76 Mb	Chr 11: 118.88 – 118.89 Mb
PubMed search	[1]	[2]

Chromobox protein homolog 2 is a protein that in humans is encoded by the CBX2 gene.^[1][2][3] According to a New Scientist CBX2 controls human gender even more so than X/Y chromosomes^[4].

Interactions

CBX2 (gene) has been shown to interact with RYBP.^[5]

References

1. ^ Gecz J, Gaunt SJ, Passage E, Burton RD, Cudrey C, Pearce JJ, Fontes M (Jul 1995). "Assignment of a Polycomb-like chromobox gene (CBX2) to human chromosome 17q25". Genomics 26 (1): 130–3. doi:10.1016/0888-7543(95)80091-Y. PMID 7782071. 
2. ^ Chodak GW (Nov 1989). "Early detection and screening for prostatic cancer". Urology 34 (4 Suppl): 10–2; discussion 46–56. doi:10.1016/0090-4295(89)90228-8. PMID 2477932. 
3. ^ "Entrez Gene: CBX2 chromobox homolog 2 (Pc class homolog, Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84733. 
4. ^ Ewen Callaway. "Girl with Y chromosome sheds light on maleness ", New Scientist, 2009-04-09. Retrieved on 2009-04-14.
5. ^ García, E; Marcos-Gutiérrez C, del Mar Lorente M, Moreno J C, Vidal M (Jun. 1999). "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1". EMBO J. (ENGLAND) 18 (12): 3404–18. doi:10.1093/emboj/18.12.3404. ISSN 0261-4189. PMC 1171420. PMID 10369680. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171420. 

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• García E, Marcos-Gutiérrez C, del Mar Lorente M, et al. (1999). "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1". EMBO J. 18 (12): 3404–18. doi:10.1093/emboj/18.12.3404. PMC 1171420. PMID 10369680. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171420. 
• Katoh-Fukui Y, Tsuchiya R, Shiroishi T, et al. (1998). "Male-to-female sex reversal in M33 mutant mice". Nature 393 (6686): 688–92. doi:10.1038/31482. PMID 9641679. 
• Pearce JJ, Singh PB, Gaunt SJ (1992). "The mouse has a Polycomb-like chromobox gene". Development 114 (4): 921–9. PMID 1352241.