OTUB2

OTU domain, ubiquitin aldehyde binding 2
PDB rendering based on 1tff.
Available structures PDB 1tff
Identifiers
Symbols	OTUB2; C14orf137; FLJ21916; MGC3102; OTB2; OTU2
External IDs	OMIM: 608338 MGI: 1915399 HomoloGene: 57056 GeneCards: OTUB2 Gene
EC number	3.4.19.12
Gene Ontology Molecular function • ubiquitin-specific protease activity • ubiquitin-specific protease activity • protein binding • peptidase activity • cysteine-type peptidase activity • omega peptidase activity Cellular component • cellular_component Biological process • cellular amino acid metabolic process • protein deubiquitination • protein metabolic process • protein K63-linked deubiquitination • protein K48-linked deubiquitination Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	78990	68149
Ensembl	ENSG00000089723	ENSMUSG00000021203
UniProt	Q96DC9	Q9CQX0
RefSeq (mRNA)	NM_023112	NM_026580
RefSeq (protein)	NP_075601	NP_080856
Location (UCSC)	Chr 14: 94.49 – 94.52 Mb	Chr 12: 104.63 – 104.64 Mb
PubMed search	[1]	[2]

Ubiquitin thioesterase OTUB2 is an enzyme that in humans is encoded by the OTUB2 gene.^[1][2]

Otubains are deubiquitylating cysteine proteases (DUBs; see MIM 602519) that belong to the ovarian tumor (OTU) protein superfamily. Like other DUBs, otubains cleave proteins precisely at the ubiquitin (UB; see MIM 191339)-protein bond.[supplied by OMIM]^[2]

References

1. ^ Balakirev MY, Tcherniuk SO, Jaquinod M, Chroboczek J (Apr 2003). "Otubains: a new family of cysteine proteases in the ubiquitin pathway". EMBO Rep 4 (5): 517–22. doi:10.1038/sj.embor.embor824. PMC 1319179. PMID 12704427. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1319179. 
2. ^ ^{a b} "Entrez Gene: OTUB2 OTU domain, ubiquitin aldehyde binding 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=78990. 

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Nanao MH, Tcherniuk SO, Chroboczek J, et al. (2005). "Crystal structure of human otubain 2.". EMBO Rep. 5 (8): 783–8. doi:10.1038/sj.embor.7400201. PMC 1299112. PMID 15258613. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1299112. 
• Namciu SJ, Friedman RD, Marsden MD, et al. (2004). "Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1.". Mamm. Genome 15 (3): 162–78. doi:10.1007/s00335-003-2311-y. PMID 15014966. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14.". Nature 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.