PDE2A

Phosphodiesterase 2A, cGMP-stimulated
PDB rendering based on 1mc0.
Available structures PDB 1Z1L, 3IBJ, 3ITM, 3ITU
Identifiers
Symbols	PDE2A; PDE2A1; PED2A4
External IDs	OMIM: 602658 MGI: 2446107 HomoloGene: 1952 GeneCards: PDE2A Gene
EC number	3.1.4.17
Gene Ontology Molecular function • nucleotide binding • 3',5'-cyclic-AMP phosphodiesterase activity • cGMP-stimulated cyclic-nucleotide phosphodiesterase activity • protein binding • phosphoric diester hydrolase activity • hydrolase activity • cAMP binding • cGMP binding • protein homodimerization activity • metal ion binding • 3',5'-cyclic-GMP phosphodiesterase activity Cellular component • cytosol • cytosol • membrane • membrane raft Biological process • cAMP catabolic process • signal transduction • blood coagulation • platelet activation • cGMP catabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5138	207728
Ensembl	ENSG00000186642	ENSMUSG00000030653
UniProt	O00408	Q3TYU3
RefSeq (mRNA)	NM_001143839.2	NM_001008548
RefSeq (protein)	NP_001137311.1	NP_001008548
Location (UCSC)	Chr 11: 72.29 – 72.39 Mb	Chr 7: 108.57 – 108.66 Mb
PubMed search	[1]	[2]

cGMP-dependent 3',5'-cyclic phosphodiesterase is an enzyme that in humans is encoded by the PDE2A gene.^[1][2]

References

1. ^ Rosman GJ, Martins TJ, Sonnenburg WK, Beavo JA, Ferguson K, Loughney K (Aug 1997). "Isolation and characterization of human cDNAs encoding a cGMP-stimulated 3',5'-cyclic nucleotide phosphodiesterase". Gene 191 (1): 89–95. doi:10.1016/S0378-1119(97)00046-2. PMID 9210593. 
2. ^ "Entrez Gene: PDE2A phosphodiesterase 2A, cGMP-stimulated". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5138. 

Further reading

• Witzenrath M, Gutbier B, Schmeck B et al. (2005). "Phosphodiesterase 2 inhibition diminished acute lung injury in murine pneumococcal pneumonia". Critical Care Medicine 105 (9): 584–590. doi:10.1097/CCM.0b013e3181959814. PMID 19114892. 
• Seybold J, Thomas D, Witzenrath M et al. (2009). "Tumor necrosis factor-alpha-dependent expression of phosphodiesterase 2: role in endothelial hyperpermeability". Blood 37 (2): 3569–3576. doi:10.1182/blood-2004-07-2729. PMID 15650061. 
• Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Martinez SE, Wu AY, Glavas NA et al. (2002). "The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding". Proc. Natl. Acad. Sci. U.S.A. 99 (20): 13260–13265. doi:10.1073/pnas.192374899. PMC 130621. PMID 12271124. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=130621. 
• Manns JM, Brenna KJ, Colman RW, Sheth SB (2002). "Differential regulation of human platelet responses by cGMP inhibited and stimulated cAMP phosphodiesterases". Thromb. Haemost. 87 (5): 873–9. PMID 12038792. 
• Zauli G, Milani D, Mirandola P et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–491. doi:10.1096/fj.00-0354com. PMID 11156964. 
• Sadhu K, Hensley K, Florio VA, Wolda SL (1999). "Differential expression of the cyclic GMP-stimulated phosphodiesterase PDE2A in human venous and capillary endothelial cells". J. Histochem. Cytochem. 47 (7): 895–906. doi:10.1177/002215549904700707. PMID 10375378.