DEF6

Differentially expressed in FDCP 6 homolog (mouse)
Identifiers
Symbols	DEF6; IBP; SLAT; SWAP70L
External IDs	OMIM: 610094 MGI: 1346328 HomoloGene: 11103 GeneCards: DEF6 Gene
Gene Ontology Cellular component • nucleus • cytoplasm • plasma membrane Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	50619	23853
Ensembl	ENSG00000023892	ENSMUSG00000002257
UniProt	Q9H4E7	n/a
RefSeq (mRNA)	NM_022047	NM_027185.3
RefSeq (protein)	NP_071330	NP_081461.2
Location (UCSC)	Chr 6: 35.27 – 35.29 Mb	Chr 17: 28.34 – 28.37 Mb
PubMed search	[1]	[2]

Differentially expressed in FDCP 6 homolog is a protein that in humans is encoded by the DEF6 gene.^[1][2]

References

1. ^ Mehta H, Glogauer M, Becart S, Altman A, Coggeshall KM (Apr 2009). "Adaptor protein SLAT modulates Fcgamma receptor-mediated phagocytosis in murine macrophages". J Biol Chem 284 (18): 11882–91. doi:10.1074/jbc.M809712200. PMC 2673257. PMID 19251698. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2673257. 
2. ^ "Entrez Gene: DEF6 differentially expressed in FDCP 6 homolog (mouse)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50619. 

Further reading

• Oka T, Ihara S, Fukui Y (2007). "Cooperation of DEF6 with activated Rac in regulating cell morphology.". J. Biol. Chem. 282 (3): 2011–8. doi:10.1074/jbc.M605153200. PMID 17121847. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Mavrakis KJ, McKinlay KJ, Jones P, Sablitzky F (2004). "DEF6, a novel PH-DH-like domain protein, is an upstream activator of the Rho GTPases Rac1, Cdc42, and RhoA.". Exp. Cell Res. 294 (2): 335–44. doi:10.1016/j.yexcr.2003.12.004. PMID 15023524. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Gupta S, Fanzo JC, Hu C, et al. (2003). "T cell receptor engagement leads to the recruitment of IBP, a novel guanine nucleotide exchange factor, to the immunological synapse.". J. Biol. Chem. 278 (44): 43541–9. doi:10.1074/jbc.M308960200. PMID 12923183. 
• Gupta S, Lee A, Hu C, et al. (2004). "Molecular cloning of IBP, a SWAP-70 homologous GEF, which is highly expressed in the immune system.". Hum. Immunol. 64 (4): 389–401. doi:10.1016/S0198-8859(03)00024-7. PMID 12651066. 
• Tanaka Y, Bi K, Kitamura R, et al. (2003). "SWAP-70-like adapter of T cells, an adapter protein that regulates early TCR-initiated signaling in Th2 lineage cells.". Immunity 18 (3): 403–14. doi:10.1016/S1074-7613(03)00054-2. PMID 12648457. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.