PAFAH2

PAFAH2
Platelet-activating factor acetylhydrolase 2, 40kDa
Identifiers
Symbols PAFAH2; FLJ26025; HSD-PLA2
External IDs OMIM602344 MGI2140321 HomoloGene37309 GeneCards: PAFAH2 Gene
EC number 3.1.1.47
RNA expression pattern
PBB GE PAFAH2 205232 s at tn.png
PBB GE PAFAH2 205233 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5051 100163
Ensembl ENSG00000158006 ENSMUSG00000037366
UniProt Q99487 Q3U0K4
RefSeq (mRNA) NM_000437 NM_133880.2
RefSeq (protein) NP_000428 NP_598641.2
Location (UCSC) Chr 1:
26.29 – 26.32 Mb
Chr 4:
133.95 – 133.98 Mb
PubMed search [1] [2]

Platelet-activating factor acetylhydrolase 2, cytoplasmic is an enzyme that in humans is encoded by the PAFAH2 gene.[1][2][3]

This gene encodes platelet-activating factor acetylhydrolase isoform 2, a single-subunit intracellular enzyme that catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). However, this lipase exhibits a broader substrate specificity than simply platelet activating factor. Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist, and both are multi-subunit enzymes. Additionally, there is a single-subunit serum isoform of this enzyme.[3]

References

  1. ^ Hattori K, Adachi H, Matsuzawa A, Yamamoto K, Tsujimoto M, Aoki J, Hattori M, Arai H, Inoue K (Jan 1997). "cDNA cloning and expression of intracellular platelet-activating factor (PAF) acetylhydrolase II. Its homology with plasma PAF acetylhydrolase". J Biol Chem 271 (51): 33032–8. doi:10.1074/jbc.271.51.33032. PMID 8955149. 
  2. ^ Rice SQ, Southan C, Boyd HF, Terrett JA, MacPhee CH, Moores K, Gloger IS, Tew DG (May 1998). "Expression, purification and characterization of a human serine-dependent phospholipase A2 with high specificity for oxidized phospholipids and platelet activating factor". Biochem J 330 ( Pt 3): 1309–15. PMC 1219277. PMID 9494101. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1219277. 
  3. ^ a b "Entrez Gene: PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5051. 

Further reading


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