NDUFB7

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa
Identifiers
Symbols	NDUFB7; B18; CI-B18; MGC2480
External IDs	OMIM: 603842 MGI: 1914166 HomoloGene: 3059 GeneCards: NDUFB7 Gene
Gene Ontology Molecular function • NADH dehydrogenase activity • NADH dehydrogenase (ubiquinone) activity Cellular component • mitochondrion • mitochondrial inner membrane • mitochondrial respiratory chain complex I • mitochondrial respiratory chain complex I • mitochondrial intermembrane space • membrane • respiratory chain Biological process • mitochondrial electron transport, NADH to ubiquinone • transport • respiratory electron transport chain Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4713	66916
Ensembl	ENSG00000099795	ENSMUSG00000033938
UniProt	P17568	Q9CR61
RefSeq (mRNA)	NM_004146	NM_025843.3
RefSeq (protein)	NP_004137	NP_080119.1
Location (UCSC)	Chr 19: 14.68 – 14.68 Mb	Chr 8: 86.09 – 86.1 Mb
PubMed search	[1]	[2]

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 is an enzyme that in humans is encoded by the NDUFB7 gene.^[1][2][3]

The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It is located at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.^[3]

References

1. ^ Emahazion T, Beskow A, Gyllensten U, Brookes AJ (Nov 1998). "Intron based radiation hybrid mapping of 15 complex I genes of the human electron transport chain". Cytogenet Cell Genet 82 (1–2): 115–9. doi:10.1159/000015082. PMID 9763677. 
2. ^ Triepels R, Smeitink J, Loeffen J, Smeets R, Trijbels F, van den Heuvel L (Jun 2000). "Characterization of the human complex I NDUFB7 and 17.2-kDa cDNAs and mutational analysis of 19 genes of the HP fraction in complex I-deficient-patients". Hum Genet 106 (4): 385–91. doi:10.1007/s004390000278. PMID 10830904. 
3. ^ ^{a b} "Entrez Gene: NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4713. 

Further reading

• Smeitink J, van den Heuvel L (1999). "Human mitochondrial complex I in health and disease". Am. J. Hum. Genet. 64 (6): 1505–10. doi:10.1086/302432. PMC 1377894. PMID 10330338. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1377894. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=16901. 
• Loeffen JL, Triepels RH, van den Heuvel LP, et al. (1999). "cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed". Biochem. Biophys. Res. Commun. 253 (2): 415–22. doi:10.1006/bbrc.1998.9786. PMID 9878551. 
• Wong YC, Tsao SW, Kakefuda M, Bernal SD (1990). "cDNA cloning of a novel cell adhesion protein expressed in human squamous carcinoma cells". Biochem. Biophys. Res. Commun. 166 (2): 984–92. doi:10.1016/0006-291X(90)90908-6. PMID 2302251.