NDUFA10

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa
Identifiers
Symbols	NDUFA10; CI-42KD; CI-42k; FLJ21923; MGC5103
External IDs	OMIM: 603835 MGI: 1914523 HomoloGene: 15342 GeneCards: NDUFA10 Gene
Gene Ontology Molecular function • ATP binding • NADH dehydrogenase (ubiquinone) activity • phosphotransferase activity, alcohol group as acceptor Cellular component • mitochondrion • mitochondrial inner membrane • mitochondrial respiratory chain complex I • mitochondrial respiratory chain complex I • mitochondrial matrix • respiratory chain Biological process • mitochondrial electron transport, NADH to ubiquinone • nucleobase, nucleoside, nucleotide and nucleic acid metabolic process • transport • respiratory electron transport chain • response to drug Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4705	67273
Ensembl	ENSG00000130414	ENSMUSG00000026260
UniProt	O95299	Q3UKK0
RefSeq (mRNA)	NM_004544	NM_024197.1
RefSeq (protein)	NP_004535	NP_077159.1
Location (UCSC)	Chr 2: 240.83 – 240.96 Mb	Chr 1: 94.34 – 94.37 Mb
PubMed search	[1]	[2]

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial is an enzyme that in humans is encoded by the NDUFA10 gene.^[1][2]

The protein encoded by this gene belongs to the complex I 42kDA subunit family. Mammalian complex I is the first enzyme complex in the electron transport chain of mitochondria. It is composed of 45 different subunits. This protein is a component of the hydrophobic protein fraction and has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain.^[2]

References

1. ^ Loeffen JL, Triepels RH, van den Heuvel LP, Schuelke M, Buskens CA, Smeets RJ, Trijbels JM, Smeitink JA (Jan 1999). "cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed". Biochem Biophys Res Commun 253 (2): 415–22. doi:10.1006/bbrc.1998.9786. PMID 9878551. 
2. ^ ^{a b} "Entrez Gene: NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4705. 

Further reading

• Smeitink J, van den Heuvel L (1999). "Human mitochondrial complex I in health and disease". Am. J. Hum. Genet. 64 (6): 1505–10. doi:10.1086/302432. PMC 1377894. PMID 10330338. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1377894. 
• Ma J, Dempsey AA, Stamatiou D et al. (2007). "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects". Atherosclerosis 191 (1): 63–72. doi:10.1016/j.atherosclerosis.2006.05.032. PMID 16806233. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Gevaert K, Goethals M, Martens L et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Baens M, Chaffanet M, Aerssens J et al. (1994). "Assignment of the gene for the human proliferating cell nucleolar protein P120 (NOL1) to chromosome 12p13 by fluorescence in situ hybridization and polymerase chain reaction with somatic cell hybrids". Genomics 21 (1): 296–7. doi:10.1006/geno.1994.1267. PMID 8088812.