DNASE1L2

Deoxyribonuclease I-like 2
Identifiers
Symbols	DNASE1L2; DNAS1L2
External IDs	OMIM: 602622 MGI: 1913955 HomoloGene: 74391 GeneCards: DNASE1L2 Gene
Gene Ontology Molecular function • DNA binding • endonuclease activity • deoxyribonuclease activity • calcium ion binding • protein binding • hydrolase activity • endodeoxyribonuclease activity, producing 5'-phosphomonoesters Cellular component • extracellular region Biological process • DNA metabolic process • DNA catabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1775	66705
Ensembl	ENSG00000167968	ENSMUSG00000024136
UniProt	Q92874	Q3KQI2
RefSeq (mRNA)	NM_001374	NM_025718.3
RefSeq (protein)	NP_001365	NP_079994.2
Location (UCSC)	Chr 16: 2.29 – 2.29 Mb	Chr 17: 24.58 – 24.58 Mb
PubMed search	[1]	[2]

Deoxyribonuclease-1-like 2 is an enzyme that in humans is encoded by the DNASE1L2 gene.^[1][2][3]

References

1. ^ Rodriguez AM, Rodin D, Nomura H, Morton CC, Weremowicz S, Schneider MC (Sep 1997). "Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I". Genomics 42 (3): 507–13. doi:10.1006/geno.1997.4748. PMID 9205125. 
2. ^ Germino GG, Weinstat-Saslow D, Himmelbauer H, Gillespie GA, Somlo S, Wirth B, Barton N, Harris KL, Frischauf AM, Reeders ST (Jun 1992). "The gene for autosomal dominant polycystic kidney disease lies in a 750-kb CpG-rich region". Genomics 13 (1): 144–51. doi:10.1016/0888-7543(92)90214-D. PMID 1577479. 
3. ^ "Entrez Gene: DNASE1L2 deoxyribonuclease I-like 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1775. 

Further reading

• Jäger K, Fischer H, Tschachler E, Eckhart L (2008). "Terminal differentiation of nail matrix keratinocytes involves up-regulation of DNase1L2 but is independent of caspase-14 expression.". Differentiation 75 (10): 939–46. doi:10.1111/j.1432-0436.2007.00183.x. PMID 17490414. 
• Fischer H, Eckhart L, Mildner M, et al. (2007). "DNase1L2 degrades nuclear DNA during corneocyte formation.". J. Invest. Dermatol. 127 (1): 24–30. doi:10.1038/sj.jid.5700503. PMID 16902420. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Shiokawa D, Matsushita T, Kobayashi T, et al. (2005). "Characterization of the human DNAS1L2 gene and the molecular mechanism for its transcriptional activation induced by inflammatory cytokines". Genomics 84 (1): 95–105. doi:10.1016/j.ygeno.2004.02.003. PMID 15203207. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Shiokawa D, Tanuma S (2001). "Characterization of human DNase I family endonucleases and activation of DNase gamma during apoptosis". Biochemistry 40 (1): 143–52. doi:10.1021/bi001041a. PMID 11141064.