Endonuclease/Exonuclease/phosphatase family

Endonuclease/Exonuclease/phosphatase family

Pfam_box
Symbol = Exo_endo_phos
Name = Endonuclease/Exonuclease/phosphatase family


width =
caption =
Pfam= PF03372
InterPro= IPR005135
SMART=
Prosite = PDOC00598
SCOP = 1ako
TCDB =
OPM family= 148
OPM protein= 1zwx
PDB=PDB3|1i9yA:560-846 PDB3|1i9zA:560-846 PDB3|1si6X:29-298PDB3|1y21A:29-298 PDB3|1ntfA:29-298 PDB3|1zwxA:45-332PDB3|1ako :1-266 PDB3|1de9A:62-316 PDB3|1de8A:62-316PDB3|1cqgB:62-70 PDB3|1dewA:62-316 PDB3|1cqhB:62-70PDB3|1e9nA:62-316 PDB3|1hd7A:62-316 PDB3|1bix :62-316PDB3|1lyrA:62-316 PDB3|1xzsA:62-316 PDB3|1xzrA:62-316PDB3|1xztA:62-316 PDB3|1wduB:56-180 PDB3|1sr4B:27-281PDB3|2a41B:23-281 PDB3|1dnkA:23-281 PDB3|2a40B:23-281PDB3|2dnjA:23-281 PDB3|2a3zB:23-281 PDB3|3dni :23-281PDB3|1atnD:23-281 PDB3|2a42B:23-281

Endonuclease/Exonuclease/phosphatase family is a structural domain found in the large family of proteins including magnesium dependent endonucleases and many phosphatases involved in intracellular signaling cite journal |author=Dlaki M |title=Functionally unrelated signalling proteins contain a fold similar to Mg2+-dependent endonucleases |journal=Trends Biochem. Sci. |volume=25 |issue=6 |pages=272–273 |year=2000 |pmid=10838565 |doi=10.1016/S0968-0004(00)01582-6] .

Examples

*AP endonuclease proteins EC number|4.2.99.18,
*DNase I proteins EC number|3.1.21.1,
*Synaptojanin, an inositol-1,4,5-trisphosphate phosphatase EC number|3.1.3.56
*Sphingomyelinase EC number|3.1.4.12 and Nocturnin UniProt|O35710.

ubfamilies

*Inositol polyphosphate related phosphatase InterPro|IPR000300

Human proteins containing this domain

2'-PDE; 2-PDE; ANGEL1; ANGEL2; APEX1; APEX2; CCRN4L; CNOT6;
CNOT6L; DNASE1; DNASE1L1; DNASE1L2; DNASE1L3; INPP5A; INPP5B; INPP5D;
INPP5E; INPPL1; KIAA1706; OCRL; PIB5PA; SKIP; SMPD2; SMPD3;
SYNJ1; SYNJ2; TTRAP;

Notes

References

* [1] . Functionally unrelated signalling proteins contain a fold similar to Mg2+-dependent endonucleases. Dlakic M; Trends Biochem Sci 2000;25:272-273. PMID|10838565
* [2] . Structure and function of the multifunctional DNA-repair enzyme exonuclease III. Mol CD, Kuo CF, Thayer MM, Cunningham RP, Tainer JA; Nature 1995;374:381-386. PMID|7885481
* [3] . DNase I-induced DNA conformation. 2 A structure of a DNase I-octamer complex. Lahm A, Suck D; J Mol Biol 1991;222:645-667. PMID|1748997


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