Endonuclease/Exonuclease/phosphatase family

Endonuclease/Exonuclease/phosphatase family

Pfam_box
Symbol = Exo_endo_phos
Name = Endonuclease/Exonuclease/phosphatase family


width =
caption =
Pfam= PF03372
InterPro= IPR005135
SMART=
Prosite = PDOC00598
SCOP = 1ako
TCDB =
OPM family= 148
OPM protein= 1zwx
PDB=PDB3|1i9yA:560-846 PDB3|1i9zA:560-846 PDB3|1si6X:29-298PDB3|1y21A:29-298 PDB3|1ntfA:29-298 PDB3|1zwxA:45-332PDB3|1ako :1-266 PDB3|1de9A:62-316 PDB3|1de8A:62-316PDB3|1cqgB:62-70 PDB3|1dewA:62-316 PDB3|1cqhB:62-70PDB3|1e9nA:62-316 PDB3|1hd7A:62-316 PDB3|1bix :62-316PDB3|1lyrA:62-316 PDB3|1xzsA:62-316 PDB3|1xzrA:62-316PDB3|1xztA:62-316 PDB3|1wduB:56-180 PDB3|1sr4B:27-281PDB3|2a41B:23-281 PDB3|1dnkA:23-281 PDB3|2a40B:23-281PDB3|2dnjA:23-281 PDB3|2a3zB:23-281 PDB3|3dni :23-281PDB3|1atnD:23-281 PDB3|2a42B:23-281

Endonuclease/Exonuclease/phosphatase family is a structural domain found in the large family of proteins including magnesium dependent endonucleases and many phosphatases involved in intracellular signaling cite journal |author=Dlaki M |title=Functionally unrelated signalling proteins contain a fold similar to Mg2+-dependent endonucleases |journal=Trends Biochem. Sci. |volume=25 |issue=6 |pages=272–273 |year=2000 |pmid=10838565 |doi=10.1016/S0968-0004(00)01582-6] .

Examples

*AP endonuclease proteins EC number|4.2.99.18,
*DNase I proteins EC number|3.1.21.1,
*Synaptojanin, an inositol-1,4,5-trisphosphate phosphatase EC number|3.1.3.56
*Sphingomyelinase EC number|3.1.4.12 and Nocturnin UniProt|O35710.

ubfamilies

*Inositol polyphosphate related phosphatase InterPro|IPR000300

Human proteins containing this domain

2'-PDE; 2-PDE; ANGEL1; ANGEL2; APEX1; APEX2; CCRN4L; CNOT6;
CNOT6L; DNASE1; DNASE1L1; DNASE1L2; DNASE1L3; INPP5A; INPP5B; INPP5D;
INPP5E; INPPL1; KIAA1706; OCRL; PIB5PA; SKIP; SMPD2; SMPD3;
SYNJ1; SYNJ2; TTRAP;

Notes

References

* [1] . Functionally unrelated signalling proteins contain a fold similar to Mg2+-dependent endonucleases. Dlakic M; Trends Biochem Sci 2000;25:272-273. PMID|10838565
* [2] . Structure and function of the multifunctional DNA-repair enzyme exonuclease III. Mol CD, Kuo CF, Thayer MM, Cunningham RP, Tainer JA; Nature 1995;374:381-386. PMID|7885481
* [3] . DNase I-induced DNA conformation. 2 A structure of a DNase I-octamer complex. Lahm A, Suck D; J Mol Biol 1991;222:645-667. PMID|1748997


Wikimedia Foundation. 2010.

Игры ⚽ Нужен реферат?

Look at other dictionaries:

  • Phosphatase — A phosphatase is an enzyme that removes a phosphate group from its substrate by hydrolysing phosphoric acid monoesters into a phosphate ion and a molecule with a free hydroxyl group (see dephosphorylation). This action is directly opposite to… …   Wikipedia

  • Exonuclease III — Protein Name=Exonuclease III Symbol=? AltSymbols=ExoIII HGNCid=N/A Chromosome=N/A Arm= Band= LocusSupplementaryData= ECnumber=3.1.11.2 OMIM=N/A EntrezGene=? RefSeq=? UniProt=P09030 Exonuclease III (ExoIII) is an enzyme that belongs to the… …   Wikipedia

  • Protein tyrosine phosphatase — Protein tyrosine phosphatases (PTPs) are a group of enzymes that remove phosphate groups from phosphorylated tyrosine residues on proteins. Protein tyrosine (pTyr) phosphorylation is a common post translational modification that can create novel… …   Wikipedia

  • Restriction enzyme — Glossary Restriction …   Wikipedia

  • Deoxyribonuclease I — Identifiers Symbols DNASE1; DKFZp686H0155; DNL1; DRNI; FLJ38093; FLJ44902 External IDs …   Wikipedia

  • PDE1 — (phosphodiesterase1) is a phosphodiesterase enzyme also known as calcium and calmodulin dependent phosphodiesterase. It is one of the 11 families of phosphodiesterase (PDE1 PDE11). PDE1 has three subtypes, PDE1A, PDE1B and PDE1C which divide… …   Wikipedia

  • PDE3 — phosphodiesterase 3A, cGMP inhibited Identifiers Symbol PDE3A Entrez 5139 HUGO …   Wikipedia

  • Phosphodiesterase 2 — The PDE2 (phosphodiesterase 2) enzyme is one of 21 different phosphodiesterases (PDE) found in mammals. These different PDEs can be subdivided to 11 families (PDE1 – PDE11). The different PDEs of the same family are functionally related despite… …   Wikipedia

  • PDE4B — Phosphodiesterase 4B, cAMP specific PDB rendering based on 1f0j …   Wikipedia

  • PDE4A — Phosphodiesterase 4A, cAMP specific PDB rendering based on 1loi …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”