- STXBP5
Syntaxin binding protein 5 (tomosyn), also known as STXBP5, is a human
gene .cite web | title = Entrez Gene: STXBP5 syntaxin binding protein 5 (tomosyn)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=134957| accessdate = ]PBB_Summary
section_title =
summary_text = Syntaxin 1 is a component of the 7S and 20S SNARE complexes which are involved in docking and fusion of synaptic vesicles with the presynaptic plasma membrane. This gene encodes a syntaxin 1 binding protein. In rat, a similar protein dissociates syntaxin 1 from the Munc18/n-Sec1/rbSec1 complex to form a 10S complex, an intermediate which can be converted to the 7S SNARE complex. Thus this protein is thought to be involved in neurotransmitter release by stimulating SNARE complex formation. Alternatively spliced variants have been identified, but their biological validity has not been determined.cite web | title = Entrez Gene: STXBP5 syntaxin binding protein 5 (tomosyn)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=134957| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026
*cite journal | author=Katoh M, Katoh M |title=Identification and characterization of human LLGL4 gene and mouse Llgl4 gene in silico. |journal=Int. J. Oncol. |volume=24 |issue= 3 |pages= 737–42 |year= 2004 |pmid= 14767561 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Mungall AJ, Palmer SA, Sims SK, "et al." |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055
*cite journal | author=Widberg CH, Bryant NJ, Girotti M, "et al." |title=Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation. |journal=J. Biol. Chem. |volume=278 |issue= 37 |pages= 35093–101 |year= 2003 |pmid= 12832401 |doi= 10.1074/jbc.M304261200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Yokoyama S, Shirataki H, Sakisaka T, Takai Y |title=Three splicing variants of tomosyn and identification of their syntaxin-binding region. |journal=Biochem. Biophys. Res. Commun. |volume=256 |issue= 1 |pages= 218–22 |year= 1999 |pmid= 10066450 |doi= 10.1006/bbrc.1999.0300
*cite journal | author=Fujita Y, Shirataki H, Sakisaka T, "et al." |title=Tomosyn: a syntaxin-1-binding protein that forms a novel complex in the neurotransmitter release process. |journal=Neuron |volume=20 |issue= 5 |pages= 905–15 |year= 1998 |pmid= 9620695 |doi=PBB_Controls
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