CDS1 (gene)

CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1, also known as CDS1, is a human gene.cite web | title = Entrez Gene: CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1040| accessdate = ]

PBB_Summary
section_title =
summary_text = Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13.cite web | title = Entrez Gene: CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1040| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Liu Y, Virshup DM, White RL, Hsu LC |title=Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1alpha. |journal=Cancer Res. |volume=62 |issue= 22 |pages= 6357–61 |year= 2002 |pmid= 12438214 |doi=
*cite journal | author=Volta M, Bulfone A, Gattuso C, "et al." |title=Identification and characterization of CDS2, a mammalian homolog of the Drosophila CDP-diacylglycerol synthase gene. |journal=Genomics |volume=55 |issue= 1 |pages= 68–77 |year= 1999 |pmid= 9889000 |doi= 10.1006/geno.1998.5610
*cite journal | author=Halford S, Dulai KS, Daw SC, "et al." |title=Isolation and chromosomal localization of two human CDP-diacylglycerol synthase (CDS) genes. |journal=Genomics |volume=54 |issue= 1 |pages= 140–4 |year= 1999 |pmid= 9806839 |doi= 10.1006/geno.1998.5547
*cite journal | author=Lykidis A, Jackson PD, Rock CO, Jackowski S |title=The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content. |journal=J. Biol. Chem. |volume=272 |issue= 52 |pages= 33402–9 |year= 1998 |pmid= 9407135 |doi=
*cite journal | author=Weeks R, Dowhan W, Shen H, "et al." |title=Isolation and expression of an isoform of human CDP-diacylglycerol synthase cDNA. |journal=DNA Cell Biol. |volume=16 |issue= 3 |pages= 281–9 |year= 1997 |pmid= 9115637 |doi=
*cite journal | author=Heacock AM, Uhler MD, Agranoff BW |title=Cloning of CDP-diacylglycerol synthase from a human neuronal cell line. |journal=J. Neurochem. |volume=67 |issue= 5 |pages= 2200–3 |year= 1996 |pmid= 8863531 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes