Mcr1

The gene MCR1 is found in yeast and is being used to understand cell cycle checkpoints.^[1] Researchers are working to find a way to use this gene to create anti-cancer drugs.^[1]

Function

The most common function is found during the cell cycle when mutations occur because it becomes activated without phosphorylation and turns on Cds1.^[2] It also works with Cdk1 to get rid of the mutations that occur. If MCR 1 is not present in the cell these check points do not work properly.^[1]

References

1. ^ ^{a b c} Yin L, Locovei AM, D'Urso G (October 2008). "Activation of the DNA damage checkpoint in mutants defective in DNA replication initiation". Mol. Biol. Cell 19 (10): 4374–82. doi:10.1091/mbc.E08-01-0020. PMC 2555949. PMID 18667534. http://www.molbiolcell.org/cgi/pmidlookup?view=long&pmid=18667534. 
2. ^ "MCR1 Mcr1p [Saccharomyces cerevisiae"]. Entrez Gene. National Center for Biotechnology Information. http://www.ncbi.nlm.nih.gov/gene/853707.