- Metalloprotease inhibitor
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There are three classes of commonly used inhibitors for metalloproteinases.
- In vitro, EDTA, 1,10-phenanthroline and other chelating compounds lower the concentration of metal to the point where the metal is removed from the enzyme active site.
- Classical lock and key inhibitors such as phosphoramidon and bestatin bind tightly by approximating the transition state of the hydrolysis of the peptide, preventing it from acting on other substrates.
- Protein inhibitors such as α2-macroglobulin are known to work with metalloproteinases.
References
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