BHLHB3

Basic helix-loop-helix family, member e41
Identifiers
Symbols	BHLHE41; BHLHB3; DEC2; SHARP1; hDEC2
External IDs	OMIM: 606200 MGI: 1930704 HomoloGene: 11549 GeneCards: BHLHE41 Gene
Gene Ontology Molecular function • DNA binding • sequence-specific DNA binding transcription factor activity Cellular component • nucleus Biological process • transcription, DNA-dependent • regulation of transcription, DNA-dependent • circadian rhythm • cell proliferation • organ morphogenesis • cell differentiation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	79365	79362
Ensembl	ENSG00000123095	ENSMUSG00000030256
UniProt	Q9C0J9	Q6L8F5
RefSeq (mRNA)	NM_030762	NM_024469.1
RefSeq (protein)	NP_110389	NP_077789.1
Location (UCSC)	Chr 12: 26.27 – 26.28 Mb	Chr 6: 145.81 – 145.81 Mb
PubMed search	[1]	[2]

Class E basic helix-loop-helix protein 41 is a protein that in humans is encoded by the BHLHE41 gene.^[1][2][3]

One study has found that genetic variation in the gene may affect sleep time in mice.^[4] Another study found a mutation in people that has a similar effect, reducing the amount of sleep necessary for healthy living.^[5]

References

1. ^ Fujimoto K, Shen M, Noshiro M, Matsubara K, Shingu S, Honda K, Yoshida E, Suardita K, Matsuda Y, Kato Y (Feb 2001). "Molecular cloning and characterization of DEC2, a new member of basic helix-loop-helix proteins". Biochem Biophys Res Commun 280 (1): 164–71. doi:10.1006/bbrc.2000.4133. PMID 11162494. 
2. ^ Stevens JD, Roalson EH, Skinner MK (Dec 2008). "Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation". Differentiation 76 (9): 1006–22. doi:10.1111/j.1432-0436.2008.00285.x. PMID 18557763. 
3. ^ "Entrez Gene: BHLHB3 basic helix-loop-helix domain containing, class B, 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79365. 
4. ^ Ying He at al. (August 2009). "The Transcriptional Repressor DEC2 Regulates Sleep Length in Mammals". Science 325 (5942): 866–870. doi:10.1126/science.1174443. PMC 2884988. PMID 19679812. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2884988. 
5. ^ Don’t need much sleep? Rare gene may play role by Lauran Neergaard. Associated Press. 14 Aug 2009.

Further reading

• Grottke C, Mantwill K, Dietel M, et al. (2000). "Identification of differentially expressed genes in human melanoma cells with acquired resistance to various antineoplastic drugs.". Int. J. Cancer 88 (4): 535–46. doi:10.1002/1097-0215(20001115)88:4<535::AID-IJC4>3.0.CO;2-V. PMID 11058868. 
• Garriga-Canut M, Roopra A, Buckley NJ (2001). "The basic helix-loop-helix protein, sharp-1, represses transcription by a histone deacetylase-dependent and histone deacetylase-independent mechanism.". J. Biol. Chem. 276 (18): 14821–8. doi:10.1074/jbc.M011619200. PMID 11278948. 
• Miyazaki K, Kawamoto T, Tanimoto K, et al. (2003). "Identification of functional hypoxia response elements in the promoter region of the DEC1 and DEC2 genes.". J. Biol. Chem. 277 (49): 47014–21. doi:10.1074/jbc.M204938200. PMID 12354771. 
• Honma S, Kawamoto T, Takagi Y, et al. (2002). "Dec1 and Dec2 are regulators of the mammalian molecular clock.". Nature 419 (6909): 841–4. doi:10.1038/nature01123. PMID 12397359. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Li Y, Xie M, Song X, et al. (2003). "DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter.". J. Biol. Chem. 278 (19): 16899–907. doi:10.1074/jbc.M300596200. PMID 12624110. 
• Azmi S, Sun H, Ozog A, Taneja R (2003). "mSharp-1/DEC2, a basic helix-loop-helix protein functions as a transcriptional repressor of E box activity and Stra13 expression.". J. Biol. Chem. 278 (22): 20098–109. doi:10.1074/jbc.M210427200. PMID 12657651. 
• Oswald F, Winkler M, Cao Y, et al. (2005). "RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes.". Mol. Cell. Biol. 25 (23): 10379–90. doi:10.1128/MCB.25.23.10379-10390.2005. PMC 1291242. PMID 16287852. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1291242.