UGT1A@

UDP glucuronosyltransferase 1 family, polypeptide A cluster, also known as UGT1A@, is a human gene.cite web | title = Entrez Gene: UGT1A@ UDP glucuronosyltransferase 1 family, polypeptide A cluster| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7361| accessdate = ]

PBB_Summary
section_title =
summary_text = This RefSeq represents a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter.cite web | title = Entrez Gene: UGT1A@ UDP glucuronosyltransferase 1 family, polypeptide A cluster| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7361| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Mackenzie PI, Owens IS, Burchell B, "et al." |title=The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence. |journal=Pharmacogenetics |volume=7 |issue= 4 |pages= 255–69 |year= 1997 |pmid= 9295054 |doi=
*cite journal | author=Tukey RH, Strassburg CP |title=Human UDP-glucuronosyltransferases: metabolism, expression, and disease. |journal=Annu. Rev. Pharmacol. Toxicol. |volume=40 |issue= |pages= 581–616 |year= 2000 |pmid= 10836148 |doi= 10.1146/annurev.pharmtox.40.1.581
*cite journal | author=King CD, Rios GR, Green MD, Tephly TR |title=UDP-glucuronosyltransferases. |journal=Curr. Drug Metab. |volume=1 |issue= 2 |pages= 143–61 |year= 2001 |pmid= 11465080 |doi=
*cite journal | author=Ritter JK, Chen F, Sheen YY, "et al." |title=A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini. |journal=J. Biol. Chem. |volume=267 |issue= 5 |pages= 3257–61 |year= 1992 |pmid= 1339448 |doi=
*cite journal | author=Gong QH, Cho JW, Huang T, "et al." |title=Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus. |journal=Pharmacogenetics |volume=11 |issue= 4 |pages= 357–68 |year= 2001 |pmid= 11434514 |doi=
*cite journal | author=Kaplan M, Hammerman C, Rubaltelli FF, "et al." |title=Hemolysis and bilirubin conjugation in association with UDP-glucuronosyltransferase 1A1 promoter polymorphism. |journal=Hepatology |volume=35 |issue= 4 |pages= 905–11 |year= 2002 |pmid= 11915038 |doi= 10.1053/jhep.2002.32526
*cite journal | author=Peters WH, te Morsche RH, Roelofs HM |title=Combined polymorphisms in UDP-glucuronosyltransferases 1A1 and 1A6: implications for patients with Gilbert's syndrome. |journal=J. Hepatol. |volume=38 |issue= 1 |pages= 3–8 |year= 2003 |pmid= 12480553 |doi=
*cite journal | author=Zhang T, Haws P, Wu Q |title=Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation. |journal=Genome Res. |volume=14 |issue= 1 |pages= 79–89 |year= 2004 |pmid= 14672974 |doi= 10.1101/gr.1225204
*cite journal | author=Giuliani L, Ciotti M, Stoppacciaro A, "et al." |title=UDP-glucuronosyltransferases 1A expression in human urinary bladder and colon cancer by immunohistochemistry. |journal=Oncol. Rep. |volume=13 |issue= 2 |pages= 185–91 |year= 2005 |pmid= 15643497 |doi=
*cite journal | author=Mercke Odeberg J, Andrade J, Holmberg K, "et al." |title=UGT1A polymorphisms in a Swedish cohort and a human diversity panel, and the relation to bilirubin plasma levels in males and females. |journal=Eur. J. Clin. Pharmacol. |volume=62 |issue= 10 |pages= 829–37 |year= 2007 |pmid= 16909274 |doi= 10.1007/s00228-006-0166-3

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes