Beta-Naphthoflavone

chembox new
ImageFile=beta-Naphthoflavone.svg
ImageSize=
IUPACName=3-phenyl-1"H"-benzo ["f"] chromen-1-one
OtherNames=5,6-Benzoflavone, BNF
Section1=Chembox Identifiers
CASNo=6051-87-2
PubChem=2361
SMILES=C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=CC4=CC=CC=C43
Section2=Chembox Properties
C=19 |H=12 |O=2
Appearance=
Density=
MeltingPt=
BoilingPt=
Solubility=
Section3=Chembox Hazards
MainHazards=
FlashPt=
Autoignition=

beta-Naphthoflavone, also known as 5,6-benzoflavone, is a potent inducer of UGT1A. [cite journal |author=Chlouchi A, Girard C, Bonet A, Viollon-Abadie C, Heyd B, Mantion G, Martin H, Richert L |title=Effect of chrysin and natural coumarins on UGT1A1 and 1A6 activities in rat and human hepatocytes in primary culture |journal=Planta Med|volume=73 |issue=8 |pages=742-7|year=2007 |pmid=17599282] β-Naphthoflavone is a putative chemopreventive agent. [cite journal |author=Izzotti A, Bagnasco M, Cartiglia C, Longobardi M, Camoirano A, Tampa E, Lubet RA, De Flora S |title=Modulation of multigene expression and proteome profiles by chemopreventive agents |journal=Mutat Res |volume=11 |issue=591(1-2) |pages=212-23|year=2005 |pmid=16083920]

ee also

*Aryl hydrocarbon receptor

References