UGT1A3

UDP glucuronosyltransferase 1 family, polypeptide A3, also known as UGT1A3, is a human gene.cite web | title = Entrez Gene: UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54659| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. Substrates of this enzyme include estrone, 2-hydroxyestrone, and metabolites of benzo alpha-pyrene.cite web | title = Entrez Gene: UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54659| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Mackenzie PI, Owens IS, Burchell B, "et al." |title=The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence. |journal=Pharmacogenetics |volume=7 |issue= 4 |pages= 255–69 |year= 1997 |pmid= 9295054 |doi=
*cite journal | author=Tukey RH, Strassburg CP |title=Human UDP-glucuronosyltransferases: metabolism, expression, and disease. |journal=Annu. Rev. Pharmacol. Toxicol. |volume=40 |issue= |pages= 581–616 |year= 2000 |pmid= 10836148 |doi= 10.1146/annurev.pharmtox.40.1.581
*cite journal | author=Tukey RH, Strassburg CP |title=Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract. |journal=Mol. Pharmacol. |volume=59 |issue= 3 |pages= 405–14 |year= 2001 |pmid= 11179432 |doi=
*cite journal | author=King CD, Rios GR, Green MD, Tephly TR |title=UDP-glucuronosyltransferases. |journal=Curr. Drug Metab. |volume=1 |issue= 2 |pages= 143–61 |year= 2001 |pmid= 11465080 |doi=
*cite journal | author=Ritter JK, Chen F, Sheen YY, "et al." |title=A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini. |journal=J. Biol. Chem. |volume=267 |issue= 5 |pages= 3257–61 |year= 1992 |pmid= 1339448 |doi=
*cite journal | author=Moghrabi N, Sutherland L, Wooster R, "et al." |title=Chromosomal assignment of human phenol and bilirubin UDP-glucuronosyltransferase genes (UGT1A-subfamily). |journal=Ann. Hum. Genet. |volume=56 |issue= Pt 2 |pages= 81–91 |year= 1992 |pmid= 1503396 |doi=
*cite journal | author=Mojarrabi B, Butler R, Mackenzie PI |title=cDNA cloning and characterization of the human UDP glucuronosyltransferase, UGT1A3. |journal=Biochem. Biophys. Res. Commun. |volume=225 |issue= 3 |pages= 785–90 |year= 1996 |pmid= 8780690 |doi= 10.1006/bbrc.1996.1251
*cite journal | author=Strassburg CP, Manns MP, Tukey RH |title=Differential down-regulation of the UDP-glucuronosyltransferase 1A locus is an early event in human liver and biliary cancer. |journal=Cancer Res. |volume=57 |issue= 14 |pages= 2979–85 |year= 1997 |pmid= 9230212 |doi=
*cite journal | author=Strassburg CP, Oldhafer K, Manns MP, Tukey RH |title=Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue. |journal=Mol. Pharmacol. |volume=52 |issue= 2 |pages= 212–20 |year= 1997 |pmid= 9271343 |doi=
*cite journal | author=Strassburg CP, Manns MP, Tukey RH |title=Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8. |journal=J. Biol. Chem. |volume=273 |issue= 15 |pages= 8719–26 |year= 1998 |pmid= 9535849 |doi=
*cite journal | author=Green MD, King CD, Mojarrabi B, "et al." |title=Glucuronidation of amines and other xenobiotics catalyzed by expressed human UDP-glucuronosyltransferase 1A3. |journal=Drug Metab. Dispos. |volume=26 |issue= 6 |pages= 507–12 |year= 1998 |pmid= 9616184 |doi=
*cite journal | author=Strassburg CP, Kneip S, Topp J, "et al." |title=Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine. |journal=J. Biol. Chem. |volume=275 |issue= 46 |pages= 36164–71 |year= 2000 |pmid= 10748067 |doi= 10.1074/jbc.M002180200
*cite journal | author=Barbier O, Albert C, Martineau I, "et al." |title=Glucuronidation of the nonsteroidal antiestrogen EM-652 (SCH 57068), by human and monkey steroid conjugating UDP-glucuronosyltransferase enzymes. |journal=Mol. Pharmacol. |volume=59 |issue= 3 |pages= 636–45 |year= 2001 |pmid= 11179460 |doi=
*cite journal | author=Gong QH, Cho JW, Huang T, "et al." |title=Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus. |journal=Pharmacogenetics |volume=11 |issue= 4 |pages= 357–68 |year= 2001 |pmid= 11434514 |doi=
*cite journal | author=Turgeon D, Chouinard S, Belanger P, "et al." |title=Glucuronidation of arachidonic and linoleic acid metabolites by human UDP-glucuronosyltransferases. |journal=J. Lipid Res. |volume=44 |issue= 6 |pages= 1182–91 |year= 2004 |pmid= 12639971 |doi= 10.1194/jlr.M300010-JLR200
*cite journal | author=Zhang JY, Zhan J, Cook CS, "et al." |title=Involvement of human UGT2B7 and 2B15 in rofecoxib metabolism. |journal=Drug Metab. Dispos. |volume=31 |issue= 5 |pages= 652–8 |year= 2003 |pmid= 12695355 |doi=

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