DCLRE1B

DNA cross-link repair 1B
Identifiers
Symbols	DCLRE1B; APOLLO; DKFZp686C24187; FLJ12810; FLJ13998; SNM1B; SNMIB
External IDs	OMIM: 609683 MGI: 2156057 HomoloGene: 32553 GeneCards: DCLRE1B Gene
Gene Ontology Molecular function • protein binding • 5'-3' exonuclease activity • hydrolase activity Cellular component • chromosome, telomeric region • nucleus • chromosome • cytoplasm • centrosome • cytoskeleton Biological process • cell cycle checkpoint • telomere maintenance • DNA repair • telomeric loop formation • protection from non-homologous end joining at telomere • telomeric 3' overhang formation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	64858	140917
Ensembl	ENSG00000118655	ENSMUSG00000027845
UniProt	Q9H816	A0JLW2
RefSeq (mRNA)	NM_022836	NM_001025312
RefSeq (protein)	NP_073747	NP_001020483
Location (UCSC)	Chr 1: 114.45 – 114.46 Mb	Chr 3: 103.6 – 103.61 Mb
PubMed search	[1]	[2]

DNA cross-link repair 1B protein is a protein that in humans is encoded by the DCLRE1B gene.^[1]

DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1B is one of several evolutionarily conserved genes involved in repair of interstrand cross-links (Dronkert et al., 2000).[supplied by OMIM]^[1]

References

1. ^ ^{a b} "Entrez Gene: DCLRE1B DNA cross-link repair 1B (PSO2 homolog, S. cerevisiae)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64858. 

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Demuth I, Digweed M, Concannon P (2004). "Human SNM1B is required for normal cellular response to both DNA interstrand crosslink-inducing agents and ionizing radiation.". Oncogene 23 (53): 8611–8. doi:10.1038/sj.onc.1207895. PMID 15467758. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Ishiai M, Kimura M, Namikoshi K, et al. (2004). "DNA cross-link repair protein SNM1A interacts with PIAS1 in nuclear focus formation.". Mol. Cell. Biol. 24 (24): 10733–41. doi:10.1128/MCB.24.24.10733-10741.2004. PMC 533992. PMID 15572677. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=533992. 
• Freibaum BD, Counter CM (2006). "hSnm1B is a novel telomere-associated protein.". J. Biol. Chem. 281 (22): 15033–6. doi:10.1074/jbc.C600038200. PMID 16606622. 
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414. 
• Lenain C, Bauwens S, Amiard S, et al. (2006). "The Apollo 5' exonuclease functions together with TRF2 to protect telomeres from DNA repair.". Curr. Biol. 16 (13): 1303–10. doi:10.1016/j.cub.2006.05.021. PMID 16730175. 
• van Overbeek M, de Lange T (2006). "Apollo, an Artemis-related nuclease, interacts with TRF2 and protects human telomeres in S phase.". Curr. Biol. 16 (13): 1295–302. doi:10.1016/j.cub.2006.05.022. PMID 16730176.