DUSP13

Dual specificity phosphatase 13
PDB rendering based on 2gwo.
Available structures PDB 2GWO, 2PQ5
Identifiers
Symbols	DUSP13; BEDP; DUSP13A; DUSP13B; FLJ32450; MDSP; SKRP4; TMDP
External IDs	OMIM: 613191 MGI: 1351599 HomoloGene: 121604 GeneCards: DUSP13 Gene
Gene Ontology Molecular function • protein tyrosine phosphatase activity • protein tyrosine/serine/threonine phosphatase activity • protein tyrosine/serine/threonine phosphatase activity • hydrolase activity Cellular component • cytoplasm Biological process • protein dephosphorylation • meiosis • spermatogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51207	27389
Ensembl	ENSG00000079393	ENSMUSG00000021768
UniProt	A6NJZ1	Q497R2
RefSeq (mRNA)	NM_001007271.1	NM_001007268
RefSeq (protein)	NP_001007272.1	NP_001007269
Location (UCSC)	Chr 10: 76.85 – 76.87 Mb	Chr 14: 20.52 – 20.54 Mb
PubMed search	[1]	[2]

Dual specificity phosphatase 13 is an enzyme that in humans is encoded by the DUSP13 gene.^[1]

Function

Members of the protein tyrosine phosphatase superfamily cooperate with protein kinases to regulate cell proliferation and differentiation. This superfamily is separated into two families based on the substrate that is dephosphorylated. One family, the dual specificity phosphatases (DSPs) acts on both phosphotyrosine and phosphoserine/threonine residues. This gene encodes different but related DSP proteins through the use of non-overlapping open reading frames, alternate splicing, and presumed different transcription promoters. Expression of the distinct proteins from this gene has been found to be tissue specific and the proteins may be involved in postnatal development of specific tissues. A protein encoded by the upstream ORF was found in skeletal muscle, whereas the encoded protein from the downstream ORF was found only in testis. In mouse, a similar pattern of expression was found. Multiple alternatively spliced transcript variants were described, but the full-length sequence of only some were determined.^[1]

References

1. ^ ^{a b} "Entrez Gene: DUSP13 dual specificity phosphatase 13". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51207. 

Further reading

• Nakamura K, Shima H, Watanabe M et al. (2000). "Molecular cloning and characterization of a novel dual-specificity protein phosphatase possibly involved in spermatogenesis". Biochem. J. 344 Pt 3 (Pt 3): 819–25. PMC 1220704. PMID 10585869. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1220704. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Deloukas P, Earthrowl ME, Grafham DV et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054. 
• Chen HH, Luche R, Wei B, Tonks NK (2004). "Characterization of two distinct dual specificity phosphatases encoded in alternative open reading frames of a single gene located on human chromosome 10q22.2". J. Biol. Chem. 279 (40): 41404–13. doi:10.1074/jbc.M405286200. PMID 15252030. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Barrios-Rodiles M, Brown KR, Ozdamar B et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153. 
• Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Kim SJ, Jeong DG, Yoon TS et al. (2007). "Crystal structure of human TMDP, a testis-specific dual specificity protein phosphatase: implications for substrate specificity". Proteins 66 (1): 239–45. doi:10.1002/prot.21197. PMID 17044055.