NKTR

Natural killer-tumor recognition sequence
PDB rendering based on 2he9.
Available structures PDB 2he9
Identifiers
Symbols	NKTR; DKFZp686F1754; DKFZp686G0426; DKFZp686J06106; DKFZp686N24126; MGC90527; p104
External IDs	OMIM: 161565 MGI: 97346 HomoloGene: 122148 GeneCards: NKTR Gene
EC number	5.2.1.8
Gene Ontology Molecular function • peptidyl-prolyl cis-trans isomerase activity • cyclosporin A binding • isomerase activity Cellular component • membrane Biological process • protein folding Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4820	18087
Ensembl	ENSG00000114857	ENSMUSG00000032525
UniProt	P30414	Q3TQ51
RefSeq (mRNA)	NM_005385.3	NM_010918.2
RefSeq (protein)	NP_005376.2	NP_035048.3
Location (UCSC)	Chr 3: 42.64 – 42.69 Mb	Chr 9: 121.63 – 121.67 Mb
PubMed search	[1]	[2]

NK-tumor recognition protein is a protein that in humans is encoded by the NKTR gene.^[1][2][3]

This gene encodes a membrane-anchored protein with a hydrophobic amino terminal domain and a cyclophilin-like PPIase domain. It is present on the surface of natural killer cells and facilitates their binding to targets. Its expression is regulated by IL2 activation of the cells.^[3]

References

1. ^ Young HA, Jenkins NA, Copeland NG, Simek S, Lerman MI, Zbar B, Glenn G, Ortaldo JR, Anderson SK (Jul 1993). "Localization of a novel natural killer triggering receptor locus to human chromosome 3p23-p21 and mouse chromosome 9". Genomics 16 (2): 548–549. doi:10.1006/geno.1993.1229. PMID 8314596. 
2. ^ Chambers CA, Gallinger S, Anderson SK, Giardina S, Ortaldo JR, Hozumi N, Roder J (May 1994). "Expression of the NK-TR gene is required for NK-like activity in human T cells". J Immunol 152 (6): 2669–74. PMID 8144875. 
3. ^ ^{a b} "Entrez Gene: NKTR natural killer-tumor recognition sequence". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4820. 

Further reading

• Frey JL, Bino T, Kantor RR et al. (1992). "Mechanism of target cell recognition by natural killer cells: characterization of a novel triggering molecule restricted to CD3- large granular lymphocytes". J. Exp. Med. 174 (6): 1527–1536. doi:10.1084/jem.174.6.1527. PMC 2119033. PMID 1720812. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2119033. 
• Rinfret A, Anderson SK (1993). "IL-2 regulates the expression of the NK-TR gene via an alternate RNA splicing mechanism". Mol. Immunol. 30 (14): 1307–1313. doi:10.1016/0161-5890(93)90047-F. PMID 8413330. 
• Anderson SK, Gallinger S, Roder J et al. (1993). "A cyclophilin-related protein involved in the function of natural killer cells". Proc. Natl. Acad. Sci. U.S.A. 90 (2): 542–546. doi:10.1073/pnas.90.2.542. PMC 45699. PMID 8421688. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=45699. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039. 
• Sakashita E, Tatsumi S, Werner D et al. (2004). "Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo". Mol. Cell. Biol. 24 (3): 1174–1187. doi:10.1128/MCB.24.3.1174-1187.2004. PMC 321435. PMID 14729963. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=321435. 
• Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983.