NPTN

Neuroplastin
Identifiers
Symbols	NPTN; DKFZp686L2477; GP55; GP65; MGC102805; SDFR1; SDR1; np55; np65
External IDs	OMIM: 612820 HomoloGene: 7531 GeneCards: NPTN Gene
Gene Ontology Molecular function • type 1 fibroblast growth factor receptor binding • cell adhesion molecule binding Cellular component • plasma membrane • integral to membrane • presynaptic membrane Biological process • positive regulation of protein phosphorylation • cell adhesion • homophilic cell adhesion • elevation of cytosolic calcium ion concentration • nervous system development • positive regulation of neuron projection development • positive regulation of fibroblast growth factor receptor signaling pathway • positive regulation of long-term neuronal synaptic plasticity • long-term synaptic potentiation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	27020	n/a
Ensembl	ENSG00000156642	n/a
UniProt	Q9Y639	n/a
RefSeq (mRNA)	NM_001161363.1	n/a
RefSeq (protein)	NP_001154835.1	n/a
Location (UCSC)	Chr 15: 73.85 – 73.93 Mb	n/a
PubMed search	[1]	n/a

Neuroplastin is a protein that in humans is encoded by the NPTN gene.^[1][2][3]

Neuroplastin is a type I transmembrane protein belonging to the Ig superfamily. The protein is believed to be involved in cell-cell interactions or cell-substrate interactions. The alpha and beta transcripts show differential localization within the brain.^[3]

References

1. ^ Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474. 
2. ^ Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Jun 1997). "Large-scale concatenation cDNA sequencing". Genome Res 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139146. 
3. ^ ^{a b} "Entrez Gene: NPTN neuroplastin". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27020. 

Further reading

• Langnaese K, Beesley PW, Gundelfinger ED (1997). "Synaptic membrane glycoproteins gp65 and gp55 are new members of the immunoglobulin superfamily.". J. Biol. Chem. 272 (2): 821–7. doi:10.1074/jbc.272.2.821. PMID 8995369. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. 
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2286551. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Saito A, Fujikura-Ouchi Y, Kuramasu A, et al. (2007). "Association study of putative promoter polymorphisms in the neuroplastin gene and schizophrenia.". Neurosci. Lett. 411 (3): 168–73. doi:10.1016/j.neulet.2006.08.042. PMID 17123723. 
• Bernstein HG, Smalla KH, Bogerts B, et al. (2007). "The immunolocalization of the synaptic glycoprotein neuroplastin differs substantially between the human and the rodent brain.". Brain Res. 1134 (1): 107–12. doi:10.1016/j.brainres.2006.11.090. PMID 17196182.