COG2

Component of oligomeric golgi complex 2
Identifiers
Symbols	COG2; LDLC
External IDs	OMIM: 606974 MGI: 1923582 HomoloGene: 7206 GeneCards: COG2 Gene
Gene Ontology Molecular function • protein binding • protein transporter activity Cellular component • Golgi membrane • Golgi apparatus • Golgi stack • membrane • Golgi transport complex • Golgi transport complex Biological process • protein glycosylation • intracellular protein transport • intra-Golgi vesicle-mediated transport • Golgi organization • oligosaccharide biosynthetic process • protein transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	22796	76332
Ensembl	ENSG00000135775	ENSMUSG00000031979
UniProt	Q14746	Q3TAN4
RefSeq (mRNA)	NM_001145036.1	NM_029746.3
RefSeq (protein)	NP_001138508.1	NP_084022.2
Location (UCSC)	Chr 1: 230.78 – 230.83 Mb	Chr 8: 127.04 – 127.08 Mb
PubMed search	[1]	[2]

Conserved oligomeric Golgi complex subunit 2 is a protein that in humans is encoded by the COG2 gene.^[1][2]

Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG2 (Ungar et al., 2002).[supplied by OMIM]^[2]

Interactions

COG2 has been shown to interact with COG4^[3] and COG3.^[4]

References

1. ^ Podos SD, Reddy P, Ashkenas J, Krieger M (Dec 1994). "LDLC encodes a brefeldin A-sensitive, peripheral Golgi protein required for normal Golgi function". J Cell Biol 127 (3): 679–91. doi:10.1083/jcb.127.3.679. PMC 2120235. PMID 7962052. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2120235. 
2. ^ ^{a b} "Entrez Gene: COG2 component of oligomeric golgi complex 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22796. 
3. ^ Loh, Eva; Hong Wanjin (Jun. 2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex". J. Biol. Chem. (United States) 279 (23): 24640–8. doi:10.1074/jbc.M400662200. ISSN 0021-9258. PMID 15047703. 
4. ^ Loh, Eva; Hong Wanjin (Jun. 2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp". J. Biol. Chem. (United States) 277 (24): 21955–61. doi:10.1074/jbc.M202326200. ISSN 0021-9258. PMID 11929878. 

Further reading

• Salesiotis AN, Wang CK, Wang CD, et al. (1995). "Identification of novel genes from stomach cancer cell lines by differential display.". Cancer Lett. 91 (1): 47–54. doi:10.1016/0304-3835(95)03717-B. PMID 7750094. 
• Loh E, Hong W (2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp.". J. Biol. Chem. 277 (24): 21955–61. doi:10.1074/jbc.M202326200. PMID 11929878. 
• Ungar D, Oka T, Brittle EE, et al. (2002). "Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function.". J. Cell Biol. 157 (3): 405–15. doi:10.1083/jcb.200202016. PMC 2173297. PMID 11980916. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2173297. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Loh E, Hong W (2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex.". J. Biol. Chem. 279 (23): 24640–8. doi:10.1074/jbc.M400662200. PMID 15047703. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Sohda M, Misumi Y, Yoshimura S, et al. (2007). "The interaction of two tethering factors, p115 and COG complex, is required for Golgi integrity.". Traffic 8 (3): 270–84. doi:10.1111/j.1600-0854.2006.00530.x. PMID 17274799.