NKRF (gene)

NFKB repressing factor
Identifiers
Symbols	NKRF; ITBA4; NRF
External IDs	OMIM: 300440 MGI: 1924536 HomoloGene: 84816 GeneCards: NKRF Gene
Gene Ontology Molecular function • DNA binding • double-stranded RNA binding Cellular component • intracellular • nucleus • nucleolus • cytoplasm Biological process • negative regulation of transcription, DNA-dependent Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55922	77286
Ensembl	ENSG00000186416	ENSMUSG00000044149
UniProt	O15226	Q4VBF1
RefSeq (mRNA)	NM_001173487.1	NM_029891.2
RefSeq (protein)	NP_001166958.1	NP_084167.2
Location (UCSC)	Chr X: 118.72 – 118.74 Mb	Chr X: 34.43 – 34.44 Mb
PubMed search	[1]	[2]

NF-kappa-B-repressing factor is a protein that in humans is encoded by the NKRF gene.^[1][2]

This gene encodes a transcription factor that interacts with specific negative regulatory elements (NREs) to mediate transcriptional repression of certain NK-kappa-B-responsive genes. The protein localizes predominantly to the nucleolus with a small fraction found in the nucleoplasm and cytoplasm.^[2]

References

1. ^ Nourbakhsh M, Hauser H (Jan 2000). "Constitutive silencing of IFN-beta promoter is mediated by NRF (NF-kappaB-repressing factor), a nuclear inhibitor of NF-kappaB". EMBO J 18 (22): 6415–25. doi:10.1093/emboj/18.22.6415. PMC 1171704. PMID 10562553. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171704. 
2. ^ ^{a b} "Entrez Gene: NKRF NF-kappaB repressing factor". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55922. 

Further reading

• Frattini A, Faranda S, Bagnasco L, et al. (1997). "Identification of a new member (ZNF183) of the Ring finger gene family in Xq24-25.". Gene 192 (2): 291–8. doi:10.1016/S0378-1119(97)00108-X. PMID 9224902. 
• Feng X, Guo Z, Nourbakhsh M, et al. (2002). "Identification of a negative response element in the human inducible nitric-oxide synthase (hiNOS) promoter: The role of NF-kappa B-repressing factor (NRF) in basal repression of the hiNOS gene.". Proc. Natl. Acad. Sci. U.S.A. 99 (22): 14212–7. doi:10.1073/pnas.212306199. PMC 137863. PMID 12381793. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=137863. 
• Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus.". Mol. Biol. Cell 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=133617. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Jianfeng D, Feng J, Chaoneng J, et al. (2004). "Cloning of the correct full length cDNA of NF-kappaB-repressing factor.". Mol. Cells 16 (3): 397–401. PMID 14744032. 
• Niedick I, Froese N, Oumard A, et al. (2005). "Nucleolar localization and mobility analysis of the NF-kappaB repressing factor NRF.". J. Cell. Sci. 117 (Pt 16): 3447–58. doi:10.1242/jcs.01129. PMID 15226370. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Dreikhausen U, Hiebenthal-Millow K, Bartels M, et al. (2005). "NF-kappaB-repressing factor inhibits elongation of human immunodeficiency virus type 1 transcription by DRB sensitivity-inducing factor.". Mol. Cell. Biol. 25 (17): 7473–83. doi:10.1128/MCB.25.17.7473-7483.2005. PMC 1190279. PMID 16107696. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1190279. 
• Fukuyama R, Ng KP, Cicek M, et al. (2007). "Role of IKK and oscillatory NFkappaB kinetics in MMP-9 gene expression and chemoresistance to 5-fluorouracil in RKO colorectal cancer cells.". Mol. Carcinog. 46 (5): 402–13. doi:10.1002/mc.20288. PMID 17186550. 
• Reboll MR, Oumard A, Gazdag AC, et al. (2007). "NRF IRES activity is mediated by RNA binding protein JKTBP1 and a 14-nt RNA element.". RNA 13 (8): 1328–40. doi:10.1261/rna.545407. PMC 1924892. PMID 17592041. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1924892.