NDUFS6

NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)
Identifiers
Symbols	NDUFS6; CI-13kA; CI-13kD-A; CI13KDA
External IDs	OMIM: 603848 MGI: 107932 HomoloGene: 37935 GeneCards: NDUFS6 Gene
Gene Ontology Molecular function • NADH dehydrogenase (ubiquinone) activity • electron carrier activity Cellular component • mitochondrion • mitochondrial inner membrane • mitochondrial respiratory chain complex I • mitochondrial respiratory chain complex I • membrane • respiratory chain Biological process • mitochondrial electron transport, NADH to ubiquinone • transport • respiratory electron transport chain Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4726	407785
Ensembl	ENSG00000145494	n/a
UniProt	O75380	n/a
RefSeq (mRNA)	NM_004553	NM_010888
RefSeq (protein)	NP_004544	NP_035018.1
Location (UCSC)	Chr 5: 1.8 – 1.82 Mb	n/a
PubMed search	[1]	[2]

NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial is an enzyme that in humans is encoded by the NDUFS6 gene.^[1][2]

The multisubunit NADH:ubiquinone oxidoreductase (complex I) is the first enzyme complex in the electron transport chain of mitochondria. The iron-sulfur protein (IP) fraction is made up of 7 subunits, including NDUFS6.^[2]

See also

• NDUFS1

References

1. ^ Emahazion T, Beskow A, Gyllensten U, Brookes AJ (Nov 1998). "Intron based radiation hybrid mapping of 15 complex I genes of the human electron transport chain". Cytogenet Cell Genet 82 (1-2): 115–9. doi:10.1159/000015082. PMID 9763677. 
2. ^ ^{a b} "Entrez Gene: NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4726. 

Further reading

• Loeffen J, van den Heuvel L, Smeets R, et al. (1998). "cDNA sequence and chromosomal localization of the remaining three human nuclear encoded iron sulphur protein (IP) subunits of complex I: the human IP fraction is completed.". Biochem. Biophys. Res. Commun. 247 (3): 751–8. doi:10.1006/bbrc.1998.8882. PMID 9647766. 
• Loeffen JL, Triepels RH, van den Heuvel LP, et al. (1999). "cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed.". Biochem. Biophys. Res. Commun. 253 (2): 415–22. doi:10.1006/bbrc.1998.9786. PMID 9878551. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. 
• Kirby DM, Salemi R, Sugiana C, et al. (2004). "NDUFS6 mutations are a novel cause of lethal neonatal mitochondrial complex I deficiency.". J. Clin. Invest. 114 (6): 837–45. doi:10.1172/JCI200420683. PMC 516258. PMID 15372108. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=516258. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer.". Mamm. Genome 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. 
• Lazarou M, McKenzie M, Ohtake A, et al. (2007). "Analysis of the assembly profiles for mitochondrial- and nuclear-DNA-encoded subunits into complex I.". Mol. Cell. Biol. 27 (12): 4228–37. doi:10.1128/MCB.00074-07. PMC 1900046. PMID 17438127. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1900046.