- HBQ1
Hemoglobin, theta 1, also known as HBQ1, is a human
gene .cite web | title = Entrez Gene: HBQ1 hemoglobin, theta 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3049| accessdate = ]PBB_Summary
section_title =
summary_text = Theta-globin mRNA is found in human fetal erythroid tissue but not in adult erythroid or other nonerythroid tissue. The theta-1 gene may be expressed very early in embryonic life, perhaps sometime before 5 weeks. Theta-1 is a member of the human alpha-globin gene cluster that involves five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-2 -pseudoalpha-1 - alpha-2 - alpha-1 - theta-1 - 3'. Research supports a transcriptionally active role for the gene and a functional role for the peptide in specific cells, possibly those of early erythroid tissue.cite web | title = Entrez Gene: HBQ1 hemoglobin, theta 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3049| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Higgs DR, Vickers MA, Wilkie AO, "et al." |title=A review of the molecular genetics of the human alpha-globin gene cluster. |journal=Blood |volume=73 |issue= 5 |pages= 1081–104 |year= 1989 |pmid= 2649166 |doi=
*cite journal | author=Giardina B, Messana I, Scatena R, Castagnola M |title=The multiple functions of hemoglobin. |journal=Crit. Rev. Biochem. Mol. Biol. |volume=30 |issue= 3 |pages= 165–96 |year= 1995 |pmid= 7555018 |doi=
*cite journal | author=Kim JH, Yu CY, Bailey A, "et al." |title=Unique sequence organization and erythroid cell-specific nuclear factor-binding of mammalian theta 1 globin promoters. |journal=Nucleic Acids Res. |volume=17 |issue= 14 |pages= 5687–700 |year= 1989 |pmid= 2569721 |doi=
*cite journal | author=Ley TJ, Maloney KA, Gordon JI, Schwartz AL |title=Globin gene expression in erythroid human fetal liver cells. |journal=J. Clin. Invest. |volume=83 |issue= 3 |pages= 1032–8 |year= 1989 |pmid= 2921315 |doi=
*cite journal | author=Gonzalez-Redondo JM, Han IS, Gu YC, Huisman TH |title=Nucleotide sequence of the human theta 1-globin gene. |journal=Biochem. Genet. |volume=26 |issue= 3-4 |pages= 207–11 |year= 1988 |pmid= 3408475 |doi=
*cite journal | author=Hsu SL, Marks J, Shaw JP, "et al." |title=Structure and expression of the human theta 1 globin gene. |journal=Nature |volume=331 |issue= 6151 |pages= 94–6 |year= 1988 |pmid= 3422341 |doi= 10.1038/331094a0
*cite journal | author=Daniels RJ, Peden JF, Lloyd C, "et al." |title=Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. |journal=Hum. Mol. Genet. |volume=10 |issue= 4 |pages= 339–52 |year= 2001 |pmid= 11157797 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=De Gobbi M, Viprakasit V, Hughes JR, "et al." |title=A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter. |journal=Science |volume=312 |issue= 5777 |pages= 1215–7 |year= 2006 |pmid= 16728641 |doi= 10.1126/science.1126431PBB_Controls
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