NUDT4

NUDT4
Nudix (nucleoside diphosphate linked moiety X)-type motif 4

PDB rendering based on 2duk.
Identifiers
Symbols NUDT4; DIPP2; DIPP2alpha; DIPP2beta; DKFZp686I1281; KIAA0487
External IDs OMIM609229 MGI1918457 HomoloGene41726 GeneCards: NUDT4 Gene
EC number 3.6.1.52
RNA expression pattern
PBB GE NUDT4 212181 s at tn.png
PBB GE NUDT4 206302 s at tn.png
PBB GE NUDT4 206303 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 11163 71207
Ensembl ENSG00000173598 ENSMUSG00000020029
UniProt Q9NZJ9 Q4FJR0
RefSeq (mRNA) NM_019094.4 NM_027722.4
RefSeq (protein) NP_061967.3 NP_081998.3
Location (UCSC) Chr 12:
93.77 – 93.8 Mb
Chr 10:
95.01 – 95.03 Mb
PubMed search [1] [2]

Diphosphoinositol polyphosphate phosphohydrolase 2 is an enzyme that in humans is encoded by the NUDT4 gene.[1][2][3]

The protein encoded by this gene regulates the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to regulating intracellular trafficking. Several alternatively spliced transcript variants have been described, but the full-length nature of some variants has not been determined. Isoforms DIPP2alpha and DIPP2beta are distinguishable from each other solely by DIPP2beta possessing one additional amino acid due to intron boundary skidding in alternate splicing.[3]

References

  1. ^ Caffrey JJ, Safrany ST, Yang X, Shears SB (Jun 2000). "Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. An expanding Nudt family". J Biol Chem 275 (17): 12730–6. doi:10.1074/jbc.275.17.12730. PMID 10777568. 
  2. ^ Caffrey JJ, Shears SB (May 2001). "Genetic rationale for microheterogeneity of human diphosphoinositol polyphosphate phosphohydrolase type 2". Gene 269 (1–2): 53–60. doi:10.1016/S0378-1119(01)00446-2. PMID 11376937. 
  3. ^ a b "Entrez Gene: NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11163. 

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