NFKBIZ

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
Identifiers
Symbols	NFKBIZ; FLJ30225; FLJ34463; IKBZ; INAP; MAIL
External IDs	OMIM: 608004 MGI: 1931595 HomoloGene: 12734 GeneCards: NFKBIZ Gene
Gene Ontology Cellular component • nucleus Biological process • regulation of transcription, DNA-dependent • inflammatory response Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	64332	80859
Ensembl	ENSG00000144802	ENSMUSG00000035356
UniProt	Q9BYH8	n/a
RefSeq (mRNA)	NM_001005474.2	NM_030612
RefSeq (protein)	NP_001005474.1	NP_085115
Location (UCSC)	Chr 3: 101.55 – 101.58 Mb	Chr 16: 55.81 – 55.84 Mb
PubMed search	[1]	[2]

NF-kappa-B inhibitor zeta is a protein that in humans is encoded by the NFKBIZ gene.^[1][2][3]

This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene.^[3]

References

1. ^ Eto A, Muta T, Yamazaki S, Takeshige K (Feb 2003). "Essential roles for NF-kappa B and a Toll/IL-1 receptor domain-specific signal(s) in the induction of I kappa B-zeta". Biochem Biophys Res Commun 301 (2): 495–501. doi:10.1016/S0006-291X(02)03082-6. PMID 12565889. 
2. ^ Totzke G, Essmann F, Pohlmann S, Lindenblatt C, Janicke RU, Schulze-Osthoff K (May 2006). "A novel member of the IkappaB family, human IkappaB-zeta, inhibits transactivation of p65 and its DNA binding". J Biol Chem 281 (18): 12645–54. doi:10.1074/jbc.M511956200. PMID 16513645. 
3. ^ ^{a b} "Entrez Gene: NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64332. 

Further reading

• Kitamura H, Kanehira K, Okita K, Morimatsu M, Saito M (2000). "MAIL, a novel nuclear I kappa B protein that potentiates LPS-induced IL-6 production.". FEBS Lett. 485 (1): 53–6. doi:10.1016/S0014-5793(00)02185-2. PMID 11086164. 
• Shiina T, Morimatsu M, Kitamura H, Ito T, Kidou S, Matsubara K, Matsuda Y, Saito M, Syuto B (2001). "Genomic organization, chromosomal localization, and promoter analysis of the mouse Mail gene.". Immunogenetics. 53 (8): 649–55. doi:10.1007/s00251-001-0376-x. PMID 11797098. 
• Haruta H, Kato A, Todokoro K (2001). "Isolation of a novel interleukin-1-inducible nuclear protein bearing ankyrin-repeat motifs.". J. Biol. Chem. 276 (16): 12485–8. doi:10.1074/jbc.C100075200. PMID 11278262. 
• Yamazaki S, Muta T, Takeshige K (2001). "A novel IkappaB protein, IkappaB-zeta, induced by proinflammatory stimuli, negatively regulates nuclear factor-kappaB in the nuclei.". J. Biol. Chem. 276 (29): 27657–62. doi:10.1074/jbc.M103426200. PMID 11356851. 
• Kitamura H, Kanehira K, Shiina T, Morimatsu M, Jung BD, Akashi S, Saito M (2002). "Bacterial lipopolysaccharide induces mRNA expression of an IkappaB MAIL through toll-like receptor 4.". J. Vet. Med. Sci. 64 (5): 419–22. doi:10.1292/jvms.64.419. PMID 12069074. 
• Kitamura H, Matsushita Y, Iwanaga T, Mori K, Kanehira K, Fujikura D, Morimatsu M, Saito M (2003). "Bacterial lipopolysaccharide-induced expression of the IkappaB protein MAIL in B-lymphocytes and macrophages.". Arch.Histol.Cytol. 66 (1): 53–62. doi:10.1679/aohc.66.53. PMID 12703554. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Shiina T, Konno A, Oonuma T, Kitamura H, Imaoka K, Takeda N, Todokoro K, Morimatsu M (2004). "Targeted disruption of MAIL, a nuclear IkappaB protein, leads to severe atopic dermatitis-like disease.". J. Biol. Chem. 279 (53): 55493–8. doi:10.1074/jbc.M409770200. PMID 15491998. 
• Ito T, Morimatsu M, Oonuma T, Shiina T, Kitamura H, Syuto B (2004). "Transcriptional regulation of the MAIL gene in LPS-stimulated RAW264 mouse macrophages.". Gene. 342 (1): 137–43. doi:10.1016/j.gene.2004.07.032. PMID 15527973. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Yamamoto M, Yamazaki S, Uematsu S, et al. (2004). "Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta.". Nature 430 (6996): 218–22. doi:10.1038/nature02738. PMID 15241416. 
• Yamaji D, Kitamura H, Kimura K, Matsushita Y, Okada H, Shiina T, Morimatsu M, Saito M (2004). "Cloning of bovine MAIL and its mRNA expression in white blood cells of Holstein cows.". Vet.Immunol.Immunopathol. 98 (3-4): 175–84. doi:10.1016/j.vetimm.2003.12.004. PMID 15010226. 
• Yamazaki S, Muta T, Matsuo S, Takeshige K (2005). "Stimulus-specific induction of a novel nuclear factor-kappaB regulator, IkappaB-zeta, via Toll/Interleukin-1 receptor is mediated by mRNA stabilization.". J. Biol. Chem. 280 (2): 1678–87. doi:10.1074/jbc.M409983200. PMID 15522867. 
• Motoyama M, Yamazaki S, Eto-Kimura A, et al. (2005). "Positive and negative regulation of nuclear factor-kappaB-mediated transcription by IkappaB-zeta, an inducible nuclear protein.". J. Biol. Chem. 280 (9): 7444–51. doi:10.1074/jbc.M412738200. PMID 15618216. 
• Cowland JB, Muta T, Borregaard N (2006). "IL-1beta-specific up-regulation of neutrophil gelatinase-associated lipocalin is controlled by IkappaB-zeta.". J. Immunol. 176 (9): 5559–66. PMID 16622025. 
• Oonuma T, Morimatsu M, Ochiai K, Iwanaga T, Hashizume K (2007). "Role of NF-kappaB in constitutive expression of MAIL in epidermal keratinocytes.". J Vet Med Sci. 69 (3): 279–84. doi:10.1292/jvms.69.279. PMID 17409644. 
• Matsuo S, Yamazaki S, Takeshige K, Muta T (2007). "Crucial roles of binding sites for NF-kappaB and C/EBPs in IkappaB-zeta-mediated transcriptional activation.". Biochem. J. 405 (3): 605–15. doi:10.1042/BJ20061797. PMC 2267307. PMID 17447895. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2267307.