- NUDT9
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Nudix (nucleoside diphosphate linked moiety X)-type motif 9
PDB rendering based on 1q33.Available structures PDB 1Q33, 1QVJ Identifiers Symbols NUDT9; MGC3037; NUDT10 External IDs OMIM: 606022 MGI: 1921417 HomoloGene: 11435 GeneCards: NUDT9 Gene EC number 3.6.1.13 Gene Ontology Molecular function • hydrolase activity
• ADP-sugar diphosphatase activity
• adenosine-diphosphatase activity
• ADP-ribose diphosphatase activityCellular component • intracellular
• mitochondrionBiological process • ADP catabolic process
• IDP catabolic processSources: Amigo / QuickGO RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 53343 74167 Ensembl ENSG00000170502 ENSMUSG00000029310 UniProt Q9BW91 n/a RefSeq (mRNA) NM_024047.3 NM_028794.3 RefSeq (protein) NP_076952.1 NP_083070.2 Location (UCSC) Chr 4:
88.34 – 88.38 MbChr 5:
104.48 – 104.49 MbPubMed search [1] [2] ADP-ribose pyrophosphatase, mitochondrial is an enzyme that in humans is encoded by the NUDT9 gene.[1][2][3]
References
- ^ Perraud AL, Fleig A, Dunn CA, Bagley LA, Launay P, Schmitz C, Stokes AJ, Zhu Q, Bessman MJ, Penner R, Kinet JP, Scharenberg AM (May 2001). "ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology". Nature 411 (6837): 595–9. doi:10.1038/35079100. PMID 11385575.
- ^ Perraud AL, Shen B, Dunn CA, Rippe K, Smith MK, Bessman MJ, Stoddard BL, Scharenberg AM (Jan 2003). "NUDT9, a member of the Nudix hydrolase family, is an evolutionarily conserved mitochondrial ADP-ribose pyrophosphatase". J Biol Chem 278 (3): 1794–801. doi:10.1074/jbc.M205601200. PMID 12427752.
- ^ "Entrez Gene: NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53343.
Further reading
- Lin S, Gasmi L, Xie Y et al. (2002). "Cloning, expression and characterisation of a human Nudix hydrolase specific for adenosine 5'-diphosphoribose (ADP-ribose)". Biochim. Biophys. Acta 1594 (1): 127–35. doi:10.1016/S0167-4838(01)00296-5. PMID 11825615.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Zhang HT, Yan ZQ, Hu XB et al. (2004). "Interaction of C17orf25 with ADP-ribose pyrophosphatase NUDT9 detected via yeast two-hybrid method". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 35 (8): 747–51. PMID 12897971.
- Shen BW, Perraud AL, Scharenberg A, Stoddard BL (2003). "The crystal structure and mutational analysis of human NUDT9". J. Mol. Biol. 332 (2): 385–98. doi:10.1016/S0022-2836(03)00954-9. PMID 12948489.
- Clark HF, Gurney AL, Abaya E et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Otsuki T, Ota T, Nishikawa T et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
- Carloto A, Costas MJ, Cameselle JC et al. (2006). "The specific, submicromolar-Km ADP-ribose pyrophosphatase purified from human placenta is enzymically indistinguishable from recombinant NUDT9 protein, including a selectivity for Mn2+ as activating cation and increase in Km for ADP-ribose, both elicited by H2O2". Biochim. Biophys. Acta 1760 (10): 1545–51. doi:10.1016/j.bbagen.2006.06.003. PMID 16860484.
PDB gallery Categories:- Human proteins
- Chromosome 4 gene stubs
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