PDE1B

Phosphodiesterase 1B, calmodulin-dependent
PDB rendering based on 1taz.
Available structures PDB 1LXR, 1TAZ
Identifiers
Symbols	PDE1B; PDE1B1; PDES1B
External IDs	OMIM: 171891 MGI: 97523 HomoloGene: 37370 GeneCards: PDE1B Gene
EC number	3.1.4.17
Gene Ontology Molecular function • 3',5'-cyclic-AMP phosphodiesterase activity • calmodulin-dependent cyclic-nucleotide phosphodiesterase activity • calmodulin binding • hydrolase activity • metal ion binding • 3',5'-cyclic-GMP phosphodiesterase activity • calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity Cellular component • nucleus • nucleolus • cytoplasm • cytosol • cytosol • neuronal cell body Biological process • regulation of neurotransmitter levels • response to amphetamine • cAMP catabolic process • apoptosis • signal transduction • activation of phospholipase C activity • blood coagulation • locomotory behavior • visual learning • platelet activation • regulation of dopamine metabolic process • serotonin metabolic process • cGMP catabolic process • nerve growth factor receptor signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5153	18574
Ensembl	ENSG00000123360	ENSMUSG00000022489
UniProt	Q01064	Q6PDS5
RefSeq (mRNA)	NM_000924.3	NM_008800.1
RefSeq (protein)	NP_000915.1	NP_032826.1
Location (UCSC)	Chr 12: 54.94 – 54.97 Mb	Chr 15: 103.33 – 103.36 Mb
PubMed search	[1]	[2]

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B is an enzyme that in humans is encoded by the PDE1B gene.^[1][2][3]

References

1. ^ Jiang X, Li J, Paskind M, Epstein PM (Nov 1996). "Inhibition of calmodulin-dependent phosphodiesterase induces apoptosis in human leukemic cells". Proc Natl Acad Sci U S A 93 (20): 11236–41. doi:10.1073/pnas.93.20.11236. PMC 1074519. PMID 8855339. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1074519. 
2. ^ Yu J, Wolda SL, Frazier AL, Florio VA, Martins TJ, Snyder PB, Harris EA, McCaw KN, Farrell CA, Steiner B, Bentley JK, Beavo JA, Ferguson K, Gelinas R (Feb 1998). "Identification and characterisation of a human calmodulin-stimulated phosphodiesterase PDE1B1". Cell Signal 9 (7): 519–29. doi:10.1016/S0898-6568(97)00046-6. PMID 9419816. 
3. ^ "Entrez Gene: PDE1B phosphodiesterase 1B, calmodulin-dependent". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5153. 

Further reading

• Repaske DR, Swinnen JV, Jin SL, et al. (1992). "A polymerase chain reaction strategy to identify and clone cyclic nucleotide phosphodiesterase cDNAs. Molecular cloning of the cDNA encoding the 63-kDa calmodulin-dependent phosphodiesterase". J. Biol. Chem. 267 (26): 18683–8. PMID 1326532. 
• Spence S, Rena G, Sullivan M, et al. (1997). "Receptor-mediated stimulation of lipid signalling pathways in CHO cells elicits the rapid transient induction of the PDE1B isoform of Ca2+/calmodulin-stimulated cAMP phosphodiesterase". Biochem. J. 321 ( Pt 1) (Pt 1): 157–63. PMC 1218050. PMID 9003415. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1218050. 
• Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964. 
• Fidock M, Miller M, Lanfear J (2002). "Isolation and differential tissue distribution of two human cDNAs encoding PDE1 splice variants". Cell. Signal. 14 (1): 53–60. doi:10.1016/S0898-6568(01)00207-8. PMID 11747989. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell Proteomics 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Bender AT, Ostenson CL, Wang EH, Beavo JA (2005). "Selective up-regulation of PDE1B2 upon monocyte-to-macrophage differentiation". Proc. Natl. Acad. Sci. U.S.A. 102 (2): 497–502. doi:10.1073/pnas.0408535102. PMC 544304. PMID 15625104. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=544304. 
• Bender AT, Beavo JA (2006). "PDE1B2 regulates cGMP and a subset of the phenotypic characteristics acquired upon macrophage differentiation from a monocyte". Proc. Natl. Acad. Sci. U.S.A. 103 (2): 460–5. doi:10.1073/pnas.0509972102. PMC 1326187. PMID 16407168. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1326187.