NUCB2

Nucleobindin 2
Identifiers
Symbols	NUCB2; NEFA
External IDs	OMIM: 608020 MGI: 1858179 HomoloGene: 3676 GeneCards: NUCB2 Gene
Gene Ontology Molecular function • DNA binding • calcium ion binding Cellular component • extracellular region • extracellular space • cytoplasm • ER-Golgi intermediate compartment • Golgi apparatus • cytosol • plasma membrane Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4925	53322
Ensembl	ENSG00000070081	ENSMUSG00000030659
UniProt	P80303	Q3TV28
RefSeq (mRNA)	NM_005013	NM_016773
RefSeq (protein)	NP_005004	NP_058053
Location (UCSC)	Chr 11: 17.23 – 17.37 Mb	Chr 7: 123.65 – 123.68 Mb
PubMed search	[1]	[2]

Nucleobindin-2 is a protein that in humans is encoded by the NUCB2 gene.^[1][2]

Nucleobindin-2 is a calcium-binding EF-hand protein.[supplied by OMIM]^[2]

Interactions

NUCB2 has been shown to interact with NDN.^[3]

References

1. ^ Barnikol-Watanabe S, Gross NA, Gotz H, Henkel T, Karabinos A, Kratzin H, Barnikol HU, Hilschmann N (Feb 1995). "Human protein NEFA, a novel DNA binding/EF-hand/leucine zipper protein. Molecular cloning and sequence analysis of the cDNA, isolation and characterization of the protein". Biol Chem Hoppe Seyler 375 (8): 497–512. PMID 7811391. 
2. ^ ^{a b} "Entrez Gene: NUCB2 nucleobindin 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4925. 
3. ^ Taniguchi, N; Taniura H, Niinobe M, Takayama C, Tominaga-Yoshino K, Ogura A, Yoshikawa K (Oct. 2000). "The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm". J. Biol. Chem. (UNITED STATES) 275 (41): 31674–81. doi:10.1074/jbc.M005103200. ISSN 0021-9258. PMID 10915798. 

Further reading

• DeAngelis MM, Doucet JP, Drury S, et al. (1998). "Assembly of a high-resolution map of the Acadian Usher syndrome region and localization of the nuclear EF-hand acidic gene". Biochim. Biophys. Acta 1407 (1): 84–91. PMID 9639681. 
• Kroll KA, Otte S, Hirschfeld G, et al. (1999). "Heterologous overexpression of human NEFA and studies on the two EF-hand calcium-binding sites". Biochem. Biophys. Res. Commun. 260 (1): 1–8. doi:10.1006/bbrc.1999.0867. PMID 10381334. 
• Taniguchi N, Taniura H, Niinobe M, et al. (2000). "The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm". J. Biol. Chem. 275 (41): 31674–81. doi:10.1074/jbc.M005103200. PMID 10915798. 
• Nesselhut J, Jurgan U, Onken E, et al. (2002). "Golgi retention of human protein NEFA is mediated by its N-terminal Leu/Ile-rich region". FEBS Lett. 509 (3): 469–75. doi:10.1016/S0014-5793(01)03187-8. PMID 11749975. 
• Linē A, Stengrēvics A, Slucka Z, et al. (2002). "Serological identification and expression analysis of gastric cancer-associated genes". Br. J. Cancer 86 (11): 1824–30. doi:10.1038/sj.bjc.6600321. PMC 2375403. PMID 12087473. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2375403. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Breuza L, Halbeisen R, Jenö P, et al. (2004). "Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46". J. Biol. Chem. 279 (45): 47242–53. doi:10.1074/jbc.M406644200. PMID 15308636. 
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129. 
• Islam A, Adamik B, Hawari FI, et al. (2006). "Extracellular TNFR1 release requires the calcium-dependent formation of a nucleobindin 2-ARTS-1 complex". J. Biol. Chem. 281 (10): 6860–73. doi:10.1074/jbc.M509397200. PMID 16407280.