NDUFA6

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa
Identifiers
Symbols	NDUFA6; B14; CI-B14; LYRM6; NADHB14
External IDs	OMIM: 602138 MGI: 1914380 HomoloGene: 1861 GeneCards: NDUFA6 Gene
Gene Ontology Molecular function • NADH dehydrogenase (ubiquinone) activity Cellular component • mitochondrion • mitochondrial inner membrane • mitochondrial respiratory chain complex I • mitochondrial respiratory chain complex I • membrane • mitochondrial membrane • respiratory chain Biological process • mitochondrial electron transport, NADH to ubiquinone • transport • response to oxidative stress • respiratory electron transport chain Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4700	67130
Ensembl	ENSG00000184983	ENSMUSG00000022450
UniProt	P56556	Q9CQZ5
RefSeq (mRNA)	NM_002490	NM_025987.3
RefSeq (protein)	NP_002481	NP_080263.1
Location (UCSC)	Chr 22: 40.81 – 40.82 Mb	Chr 15: 82.18 – 82.18 Mb
PubMed search	[1]	[2]

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 is an enzyme that in humans is encoded by the NDUFA6 gene.^[1][2][3]

References

1. ^ Emahazion T, Brookes AJ (Nov 1998). "Mapping of the NDUFA2, NDUFA6, NDUFA7, NDUFB8, and NDUFS8 electron transport chain genes by intron based radiation hybrid mapping". Cytogenet Cell Genet 82 (1–2): 114. doi:10.1159/000015081. PMID 9763676. 
2. ^ Ton C, Hwang DM, Dempsey AA, Liew CC (Jan 1998). "Identification and primary structure of five human NADH-ubiquinone oxidoreductase subunits". Biochem Biophys Res Commun 241 (2): 589–94. doi:10.1006/bbrc.1997.7707. PMID 9425316. 
3. ^ "Entrez Gene: NDUFA6 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4700. 

Further reading

• Dunbar DR, Shibasaki Y, Dobbie L, et al. (1997). "In situ hybridisation mapping of genomic clones for five human respiratory chain complex I genes". Cytogenet. Cell Genet. 78 (1): 21–4. doi:10.1159/000134618. PMID 9345899. 
• Loeffen JL, Triepels RH, van den Heuvel LP, et al. (1999). "cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed". Biochem. Biophys. Res. Commun. 253 (2): 415–22. doi:10.1006/bbrc.1998.9786. PMID 9878551. 
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. 
• Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Murray J, Taylor SW, Zhang B, et al. (2003). "Oxidative damage to mitochondrial complex I due to peroxynitrite: identification of reactive tyrosines by mass spectrometry". J. Biol. Chem. 278 (39): 37223–30. doi:10.1074/jbc.M305694200. PMID 12857734. 
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=545604. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Vogel RO, Dieteren CE, van den Heuvel LP, et al. (2007). "Identification of mitochondrial complex I assembly intermediates by tracing tagged NDUFS3 demonstrates the entry point of mitochondrial subunits". J. Biol. Chem. 282 (10): 7582–90. doi:10.1074/jbc.M609410200. PMID 17209039.