PRIM2

PRIM2

Primase, polypeptide 2A, 58kDa, also known as PRIM2A, is a human gene.

PBB_Summary
section_title =
summary_text = The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a large subunit, synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The protein encoded by this gene is the large, 58 kDa primase subunit.cite web | title = Entrez Gene: PRIM2A primase, polypeptide 2A, 58kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5558| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Stadlbauer F, Brueckner A, Rehfuess C, "et al." |title=DNA replication in vitro by recombinant DNA-polymerase-alpha-primase. |journal=Eur. J. Biochem. |volume=222 |issue= 3 |pages= 781–93 |year= 1994 |pmid= 8026492 |doi=10.1111/j.1432-1033.1994.tb18925.x
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8
*cite journal | author=Shiratori A, Okumura K, Nogami M, "et al." |title=Assignment of the 49-kDa (PRIM1) and 58-kDa (PRIM2A and PRIM2B) subunit genes of the human DNA primase to chromosome bands 1q44 and 6p11.1-p12. |journal=Genomics |volume=28 |issue= 2 |pages= 350–3 |year= 1996 |pmid= 8530050 |doi=10.1006/geno.1995.1155
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3
*cite journal | author=Coll JM, Hickey RJ, Cronkey EA, "et al." |title=Mapping specific protein-protein interactions within the core component of the breast cell DNA synthesome. |journal=Oncol. Res. |volume=9 |issue= 11-12 |pages= 629–39 |year= 1998 |pmid= 9563011 |doi=
*cite journal | author=Schneider A, Smith RW, Kautz AR, "et al." |title=Primase activity of human DNA polymerase alpha-primase. Divalent cations stabilize the enzyme activity of the p48 subunit. |journal=J. Biol. Chem. |volume=273 |issue= 34 |pages= 21608–15 |year= 1998 |pmid= 9705292 |doi=10.1074/jbc.273.34.21608
*cite journal | author=Arezi B, Kirk BW, Copeland WC, Kuchta RD |title=Interactions of DNA with human DNA primase monitored with photoactivatable cross-linking agents: implications for the role of the p58 subunit. |journal=Biochemistry |volume=38 |issue= 39 |pages= 12899–907 |year= 1999 |pmid= 10504261 |doi=10.1021/bi9908991
*cite journal | author=Smith RW, Nasheuer HP |title=Control of complex formation of DNA polymerase alpha-primase and cell-free DNA replication by the C-terminal amino acids of the largest subunit p180. |journal=FEBS Lett. |volume=527 |issue= 1-3 |pages= 143–6 |year= 2002 |pmid= 12220650 |doi=10.1016/S0014-5793(02)03197-6
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Mungall AJ, Palmer SA, Sims SK, "et al." |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rush J, Moritz A, Lee KA, "et al." |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046

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