DTX1

Deltex homolog 1 (Drosophila)
Identifiers
Symbols	DTX1; hDx-1
External IDs	OMIM: 602582 MGI: 1352744 HomoloGene: 74522 GeneCards: DTX1 Gene
Gene Ontology Molecular function • transcription coactivator activity • Notch binding • protein binding • zinc ion binding • SH3 domain binding • ubiquitin protein ligase binding • metal ion binding Cellular component • nucleus • cytoplasm Biological process • transcription, DNA-dependent • transcription from RNA polymerase II promoter • cell surface receptor linked signaling pathway • regulation of Notch signaling pathway • glial cell differentiation • negative regulation of T cell differentiation • negative regulation of neuron differentiation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1840	14357
Ensembl	ENSG00000135144	ENSMUSG00000029603
UniProt	Q86Y01	Q5DTK6
RefSeq (mRNA)	NM_004416	NM_008052.3
RefSeq (protein)	NP_004407	NP_032078.2
Location (UCSC)	Chr 12: 113.5 – 113.54 Mb	Chr 5: 121.13 – 121.16 Mb
PubMed search	[1]	[2]

Protein deltex-1 is a protein that in humans is encoded by the DTX1 gene.^[1][2]

Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity.^[2]

Interactions

DTX1 has been shown to interact with EP300.^[3]

References

1. ^ Matsuno K, Eastman D, Mitsiades T, Quinn AM, Carcanciu ML, Ordentlich P, Kadesch T, Artavanis-Tsakonas S (May 1998). "Human deltex is a conserved regulator of Notch signalling". Nat Genet 19 (1): 74–8. doi:10.1038/ng0598-74. PMID 9590294. 
2. ^ ^{a b} "Entrez Gene: DTX1 deltex homolog 1 (Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1840. 
3. ^ Yamamoto, N; Yamamoto S, Inagaki F, Kawaichi M, Fukamizu A, Kishi N, Matsuno K, Nakamura K, Weinmaster G, Okano H, Nakafuku M (Nov. 2001). "Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor". J. Biol. Chem. (United States) 276 (48): 45031–40. doi:10.1074/jbc.M105245200. ISSN 0021-9258. PMID 11564735. 

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Saito T, Chiba S, Ichikawa M, et al. (2003). "Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development.". Immunity 18 (5): 675–85. doi:10.1016/S1074-7613(03)00111-0. PMID 12753744. 
• Takeyama K, Aguiar RC, Gu L, et al. (2003). "The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity.". J. Biol. Chem. 278 (24): 21930–7. doi:10.1074/jbc.M301157200. PMID 12670957. 
• Gupta-Rossi N, Storck S, Griebel PJ, et al. (2003). "Specific over-expression of deltex and a new Kelch-like protein in human germinal center B cells.". Mol. Immunol. 39 (13): 791–9. doi:10.1016/S0161-5890(03)00002-6. PMID 12617994. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Izon DJ, Aster JC, He Y, et al. (2002). "Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1.". Immunity 16 (2): 231–43. doi:10.1016/S1074-7613(02)00271-6. PMID 11869684. 
• Yamamoto N, Yamamoto S, Inagaki F, et al. (2002). "Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor.". J. Biol. Chem. 276 (48): 45031–40. doi:10.1074/jbc.M105245200. PMID 11564735. 
• Kishi N, Tang Z, Maeda Y, et al. (2001). "Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis.". Int. J. Dev. Neurosci. 19 (1): 21–35. doi:10.1016/S0736-5748(00)00071-X. PMID 11226752. 
• Lee L, Dowhanick-Morrissette J, Katz A, et al. (2001). "Chromosomal localization, genomic characterization, and mapping to the Noonan syndrome critical region of the human Deltex (DTX1) gene.". Hum. Genet. 107 (6): 577–81. doi:10.1007/s004390000431. PMID 11153911. 
• Blaumueller CM, Qi H, Zagouras P, Artavanis-Tsakonas S (1997). "Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane.". Cell 90 (2): 281–91. doi:10.1016/S0092-8674(00)80336-0. PMID 9244302. 
• Matsuno K, Diederich RJ, Go MJ, et al. (1995). "Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats.". Development 121 (8): 2633–44. PMID 7671825.