PEG3

Paternally expressed 3
Identifiers
Symbols	PEG3; DKFZp781A095; KIAA0287; PW1; ZNF904; ZSCAN24
External IDs	OMIM: 601483 MGI: 104748 HomoloGene: 31363 GeneCards: PEG3 Gene
Gene Ontology Molecular function • nucleic acid binding • sequence-specific DNA binding transcription factor activity • zinc ion binding • metal ion binding Cellular component • intracellular • nucleus • nucleolus • cytoplasm Biological process • apoptosis • viral reproduction
Orthologs
Species	Human	Mouse
Entrez	5178	18616
Ensembl	n/a	ENSMUSG00000002265
UniProt	n/a	Q0P5Y8
RefSeq (mRNA)	NM_001146184.1	NM_008817.2
RefSeq (protein)	NP_001139656.1	NP_032843.2
Location (UCSC)	n/a	Chr 7: 6.66 – 6.68 Mb
PubMed search	[1]	[2]

Paternally-expressed gene 3 protein is a protein that in humans is encoded by the PEG3 gene.^[1][2]

Interactions

PEG3 has been shown to interact with SIAH2^[3] and SIAH1.^[3]

References

1. ^ Kim J, Ashworth L, Branscomb E, Stubbs L (Aug 1997). "The human homolog of a mouse-imprinted gene, Peg3, maps to a zinc finger gene-rich region of human chromosome 19q13.4". Genome Res 7 (5): 532–40. PMC 310658. PMID 9149948. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310658. 
2. ^ "Entrez Gene: PEG3 paternally expressed 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5178. 
3. ^ ^{a b} Relaix, F; Wei X j, Li W, Pan J, Lin Y, Bowtell D D, Sassoon D A, Wu X (Feb. 2000). "Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (5): 2105–10. doi:10.1073/pnas.040378897. ISSN 0027-8424. PMC 15761. PMID 10681424. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=15761. 

Further reading

• Relaix F, Wei XJ, Wu X, Sassoon DA (1998). "Peg3/Pw1 is an imprinted gene involved in the TNF-NFkappaB signal transduction pathway.". Nat. Genet. 18 (3): 287–91. doi:10.1038/ng0398-287. PMID 9500555. 
• Relaix F, Wei X, Li W, et al. (2000). "Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis.". Proc. Natl. Acad. Sci. U.S.A. 97 (5): 2105–10. doi:10.1073/pnas.040378897. PMC 15761. PMID 10681424. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=15761. 
• Kim J, Bergmann A, Stubbs L (2000). "Exon sharing of a novel human zinc-finger gene, ZIM2, and paternally expressed gene 3 (PEG3).". Genomics 64 (1): 114–8. doi:10.1006/geno.1999.6112. PMID 10708526. 
• Kohda T, Asai A, Kuroiwa Y, et al. (2001). "Tumour suppressor activity of human imprinted gene PEG3 in a glioma cell line.". Genes Cells 6 (3): 237–47. doi:10.1046/j.1365-2443.2001.00412.x. PMID 11260267. 
• Hiby SE, Lough M, Keverne EB, et al. (2001). "Paternal monoallelic expression of PEG3 in the human placenta.". Hum. Mol. Genet. 10 (10): 1093–100. doi:10.1093/hmg/10.10.1093. PMID 11331620. 
• Yarden RI, Brody LC (2002). "Identification of proteins that interact with BRCA1 by Far-Western library screening.". J. Cell. Biochem. 83 (4): 521–31. doi:10.1002/jcb.1257. PMID 11746496. 
• Johnson MD, Wu X, Aithmitti N, Morrison RS (2002). "Peg3/Pw1 is a mediator between p53 and Bax in DNA damage-induced neuronal death.". J. Biol. Chem. 277 (25): 23000–7. doi:10.1074/jbc.M201907200. PMID 11943780. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Mirey G, Chartrain I, Froment C, et al. (2006). "CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis.". Cell Cycle 4 (6): 806–11. PMID 15908796. 
• Dowdy SC, Gostout BS, Shridhar V, et al. (2005). "Biallelic methylation and silencing of paternally expressed gene 3 (PEG3) in gynecologic cancer cell lines.". Gynecol. Oncol. 99 (1): 126–34. doi:10.1016/j.ygyno.2005.05.036. PMID 16023706. 
• Chartrain I, Couturier A, Tassan JP (2006). "Cell-cycle-dependent cortical localization of pEg3 protein kinase in Xenopus and human cells.". Biol. Cell 98 (4): 253–63. doi:10.1042/BC20050041. PMID 16159311. 
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. 

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