- PEG3
-
Paternally expressed 3 Identifiers Symbols PEG3; DKFZp781A095; KIAA0287; PW1; ZNF904; ZSCAN24 External IDs OMIM: 601483 MGI: 104748 HomoloGene: 31363 GeneCards: PEG3 Gene Gene Ontology Molecular function • nucleic acid binding
• sequence-specific DNA binding transcription factor activity
• zinc ion binding
• metal ion bindingCellular component • intracellular
• nucleus
• nucleolus
• cytoplasmBiological process • apoptosis
• viral reproductionOrthologs Species Human Mouse Entrez 5178 18616 Ensembl n/a ENSMUSG00000002265 UniProt n/a Q0P5Y8 RefSeq (mRNA) NM_001146184.1 NM_008817.2 RefSeq (protein) NP_001139656.1 NP_032843.2 Location (UCSC) n/a Chr 7:
6.66 – 6.68 MbPubMed search [1] [2] Paternally-expressed gene 3 protein is a protein that in humans is encoded by the PEG3 gene.[1][2]
Interactions
PEG3 has been shown to interact with SIAH2[3] and SIAH1.[3]
References
- ^ Kim J, Ashworth L, Branscomb E, Stubbs L (Aug 1997). "The human homolog of a mouse-imprinted gene, Peg3, maps to a zinc finger gene-rich region of human chromosome 19q13.4". Genome Res 7 (5): 532–40. PMC 310658. PMID 9149948. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310658.
- ^ "Entrez Gene: PEG3 paternally expressed 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5178.
- ^ a b Relaix, F; Wei X j, Li W, Pan J, Lin Y, Bowtell D D, Sassoon D A, Wu X (Feb. 2000). "Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (5): 2105–10. doi:10.1073/pnas.040378897. ISSN 0027-8424. PMC 15761. PMID 10681424. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=15761.
Further reading
- Relaix F, Wei XJ, Wu X, Sassoon DA (1998). "Peg3/Pw1 is an imprinted gene involved in the TNF-NFkappaB signal transduction pathway.". Nat. Genet. 18 (3): 287–91. doi:10.1038/ng0398-287. PMID 9500555.
- Relaix F, Wei X, Li W, et al. (2000). "Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis.". Proc. Natl. Acad. Sci. U.S.A. 97 (5): 2105–10. doi:10.1073/pnas.040378897. PMC 15761. PMID 10681424. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=15761.
- Kim J, Bergmann A, Stubbs L (2000). "Exon sharing of a novel human zinc-finger gene, ZIM2, and paternally expressed gene 3 (PEG3).". Genomics 64 (1): 114–8. doi:10.1006/geno.1999.6112. PMID 10708526.
- Kohda T, Asai A, Kuroiwa Y, et al. (2001). "Tumour suppressor activity of human imprinted gene PEG3 in a glioma cell line.". Genes Cells 6 (3): 237–47. doi:10.1046/j.1365-2443.2001.00412.x. PMID 11260267.
- Hiby SE, Lough M, Keverne EB, et al. (2001). "Paternal monoallelic expression of PEG3 in the human placenta.". Hum. Mol. Genet. 10 (10): 1093–100. doi:10.1093/hmg/10.10.1093. PMID 11331620.
- Yarden RI, Brody LC (2002). "Identification of proteins that interact with BRCA1 by Far-Western library screening.". J. Cell. Biochem. 83 (4): 521–31. doi:10.1002/jcb.1257. PMID 11746496.
- Johnson MD, Wu X, Aithmitti N, Morrison RS (2002). "Peg3/Pw1 is a mediator between p53 and Bax in DNA damage-induced neuronal death.". J. Biol. Chem. 277 (25): 23000–7. doi:10.1074/jbc.M201907200. PMID 11943780.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Mirey G, Chartrain I, Froment C, et al. (2006). "CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis.". Cell Cycle 4 (6): 806–11. PMID 15908796.
- Dowdy SC, Gostout BS, Shridhar V, et al. (2005). "Biallelic methylation and silencing of paternally expressed gene 3 (PEG3) in gynecologic cancer cell lines.". Gynecol. Oncol. 99 (1): 126–34. doi:10.1016/j.ygyno.2005.05.036. PMID 16023706.
- Chartrain I, Couturier A, Tassan JP (2006). "Cell-cycle-dependent cortical localization of pEg3 protein kinase in Xenopus and human cells.". Biol. Cell 98 (4): 253–63. doi:10.1042/BC20050041. PMID 16159311.
- Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
This protein-related article is a stub. You can help Wikipedia by expanding it.