DPP7

DPP7
Dipeptidyl-peptidase 7

Rendering based on PDB 3JYH.
Identifiers
Symbols DPP7; DPP2; DPPII; QPP
External IDs OMIM610537 MGI1933213 HomoloGene22748 GeneCards: DPP7 Gene
EC number 3.4.14.2
Orthologs
Species Human Mouse
Entrez 29952 83768
Ensembl ENSG00000176978 ENSMUSG00000026958
UniProt Q9UHL4 Q8R082
RefSeq (mRNA) XM_001130451 NM_031843.2
RefSeq (protein) XP_001130451 NP_114031.2
Location (UCSC) Chr 9:
140 – 140.01 Mb
Chr 2:
25.21 – 25.21 Mb
PubMed search [1] [2]

Dipeptidyl-peptidase 2 is an enzyme that in humans is encoded by the DPP7 gene.[1][2][3]

The protein encoded by this gene is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. The resting lymphocytes are maintained through suppression of apoptosis, a state which is disrupted by inhibition of this novel serine protease. The enzyme has strong sequence homology with prolylcarboxypeptidase and is active at both acidic and neutral pH.[3]

References

  1. ^ Chiravuri M, Schmitz T, Yardley K, Underwood R, Dayal Y, Huber BT (Oct 1999). "A novel apoptotic pathway in quiescent lymphocytes identified by inhibition of a post-proline cleaving aminodipeptidase: a candidate target protease, quiescent cell proline dipeptidase". J Immunol 163 (6): 3092–9. PMID 10477574. 
  2. ^ Fukasawa KM, Fukasawa K, Higaki K, Shiina N, Ohno M, Ito S, Otogoto J, Ota N (Jan 2001). "Cloning and functional expression of rat kidney dipeptidyl peptidase II". Biochem J 353 (Pt 2): 283–90. doi:10.1042/0264-6021:3530283. PMC 1221570. PMID 11139392. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1221570. 
  3. ^ a b "Entrez Gene: DPP7 dipeptidyl-peptidase 7". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29952. 

Further reading


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Look at other dictionaries:

  • Dipeptidyl peptidase — is a type of enzyme classified under EC 3.4.14. Types include: Cathepsin C, dipeptidyl peptidase 1[1] DPP3, dipeptidyl peptidase 3 Dipeptidyl peptidase 4 DPP6, dipeptidyl peptidase 6 DPP7, dipeptidyl peptidase 7 DPP8, dipeptidyl peptidase 8 DPP9 …   Wikipedia

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