- RhoD
RhoD (Ras homolog gene family, member D) is a small (~21 kDa) signaling
G protein (more specifically aGTPase ), and is a member of the Rac subfamily of the familyRho family of GTPases .cite journal |author=Ridley A. |year=2006 |title=Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking |journal=Trends Cell Biol |volume=16 |issue=10 |pages=522–9 |issn=0962-8924 |doi=10.1016/j.tcb.2006.08.006] It is encoded by the gene RHOD. cite web | title = Entrez Gene: RHOD ras homolog gene family, member D| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29984| accessdate = ]It binds GTP and is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton.
References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Ridley AJ |title=Rho proteins: linking signaling with membrane trafficking. |journal=Traffic |volume=2 |issue= 5 |pages= 303–10 |year= 2001 |pmid= 11350626 |doi=
*cite journal | author=Shimizu F, Watanabe TK, Okuno S, "et al." |title=Isolation of a novel human cDNA (rhoHP1) homologous to rho genes. |journal=Biochim. Biophys. Acta |volume=1351 |issue= 1-2 |pages= 13–6 |year= 1997 |pmid= 9116026 |doi=
*cite journal | author=Kim HS, Choi JY, Jung AR, "et al." |title=Assignment of the human RhoHP1 gene (ARHD) to chromosome 11q14.3 by radiation hybrid mapping. |journal=Cytogenet. Cell Genet. |volume=89 |issue= 1-2 |pages= 53 |year= 2000 |pmid= 10894936 |doi=
*cite journal | author=Murphy C, Saffrich R, Olivo-Marin JC, "et al." |title=Dual function of rhoD in vesicular movement and cell motility. |journal=Eur. J. Cell Biol. |volume=80 |issue= 6 |pages= 391–8 |year= 2001 |pmid= 11484930 |doi=
*cite journal | author=Zanata SM, Hovatta I, Rohm B, Püschel AW |title=Antagonistic effects of Rnd1 and RhoD GTPases regulate receptor activity in Semaphorin 3A-induced cytoskeletal collapse. |journal=J. Neurosci. |volume=22 |issue= 2 |pages= 471–7 |year= 2002 |pmid= 11784792 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gasman S, Kalaidzidis Y, Zerial M |title=RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase. |journal=Nat. Cell Biol. |volume=5 |issue= 3 |pages= 195–204 |year= 2003 |pmid= 12577064 |doi= 10.1038/ncb935
*cite journal | author=Jaffe AB, Aspenström P, Hall A |title=Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways. |journal=Mol. Cell. Biol. |volume=24 |issue= 4 |pages= 1736–46 |year= 2004 |pmid= 14749388 |doi=
*cite journal | author=Flaxenburg JA, Melter M, Lapchak PH, "et al." |title=The CD40-induced signaling pathway in endothelial cells resulting in the overexpression of vascular endothelial growth factor involves Ras and phosphatidylinositol 3-kinase. |journal=J. Immunol. |volume=172 |issue= 12 |pages= 7503–9 |year= 2004 |pmid= 15187129 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Barrios-Rodiles M, Brown KR, Ozdamar B, "et al." |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621–5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776
*cite journal | author=Birukova AA, Chatchavalvanich S, Rios A, "et al." |title=Differential regulation of pulmonary endothelial monolayer integrity by varying degrees of cyclic stretch. |journal=Am. J. Pathol. |volume=168 |issue= 5 |pages= 1749–61 |year= 2006 |pmid= 16651639 |doi=
*cite journal | author=Ito Y, Kanamaru A, Tada A |title=A novel agent, methylophiopogonanone B, promotes Rho activation and tubulin depolymerization. |journal=Mol. Cell. Biochem. |volume=297 |issue= 1-2 |pages= 121–9 |year= 2007 |pmid= 17029007 |doi= 10.1007/s11010-006-9336-y
*cite journal | author=Tan W, Martin D, Gutkind JS |title=The Galpha13-Rho signaling axis is required for SDF-1-induced migration through CXCR4. |journal=J. Biol. Chem. |volume=281 |issue= 51 |pages= 39542–9 |year= 2007 |pmid= 17056591 |doi= 10.1074/jbc.M609062200
*cite journal | author=Lakshman N, Kim A, Bayless KJ, "et al." |title=Rho plays a central role in regulating local cell-matrix mechanical interactions in 3D culture. |journal=Cell Motil. Cytoskeleton |volume=64 |issue= 6 |pages= 434–45 |year= 2007 |pmid= 17342762 |doi= 10.1002/cm.20194PBB_Controls
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