DNASE1L1

Deoxyribonuclease I-like 1
Identifiers
Symbols	DNASE1L1; DNAS1L1; DNASEX; DNL1L; XIB
External IDs	OMIM: 300081 MGI: 109628 HomoloGene: 4896 GeneCards: DNASE1L1 Gene
EC number	3.1.21.-
Gene Ontology Molecular function • DNA binding • endonuclease activity • deoxyribonuclease activity • hydrolase activity • endodeoxyribonuclease activity, producing 5'-phosphomonoesters Cellular component • endoplasmic reticulum Biological process • DNA metabolic process • DNA catabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1774	69537
Ensembl	ENSG00000013563	ENSMUSG00000019088
UniProt	P49184	Q9D7J6
RefSeq (mRNA)	NM_001009932.1	NM_027109
RefSeq (protein)	NP_001009932.1	NP_081385
Location (UCSC)	Chr X: 153.63 – 153.64 Mb	Chr X: 71.52 – 71.53 Mb
PubMed search	[1]	[2]

Deoxyribonuclease-1-like 1 is an enzyme that in humans is encoded by the DNASE1L1 gene.^[1][2][3]

This gene encodes a member of the deoxyribonuclease family and the protein shows high sequence similarity to lysosomal DNase I. Alternate transcriptional splice variants, encoding the same protein, have been characterized.^[3]

References

1. ^ Parrish JE, Ciccodicola A, Wehhert M, Cox GF, Chen E, Nelson DL (Feb 1996). "A muscle-specific DNase I-like gene in human Xq28". Hum Mol Genet 4 (9): 1557–64. doi:10.1093/hmg/4.9.1557. PMID 8541839. 
2. ^ Pergolizzi R, Appierto V, Bosetti A, DeBellis GL, Rovida E, Biunno I (Jul 1996). "Cloning of a gene encoding a DNase I-like endonuclease in the human Xq28 region". Gene 168 (2): 267–70. doi:10.1016/0378-1119(95)00741-5. PMID 8654957. 
3. ^ ^{a b} "Entrez Gene: DNASE1L1 deoxyribonuclease I-like 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1774. 

Further reading

• Chen EY, Zollo M, Mazzarella R et al. (1997). "Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci". Hum. Mol. Genet. 5 (5): 659–68. doi:10.1093/hmg/5.5.659. PMID 8733135. 
• Rodriguez AM, Rodin D, Nomura H et al. (1997). "Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I". Genomics 42 (3): 507–13. doi:10.1006/geno.1997.4748. PMID 9205125. 
• Malferrari G, Mazza U, Tresoldi C et al. (1999). "Molecular characterization of a novel endonuclease (Xib) and possible involvement in lysosomal glycogen storage disorders". Exp. Mol. Pathol. 66 (2): 123–30. doi:10.1006/exmp.1999.2254. PMID 10409440. 
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310948. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Brandenberger R, Wei H, Zhang S et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Wiemann S, Arlt D, Huber W et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528930. 
• Ross MT, Grafham DV, Coffey AJ et al. (2005). "The DNA sequence of the human X chromosome". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2665286. 
• Shiokawa D, Shika Y, Saito K et al. (2006). "Physical and biochemical properties of mammalian DNase X proteins: non-AUG translation initiation of porcine and bovine mRNAs for DNase X". Biochem. J. 392 (Pt 3): 511–7. doi:10.1042/BJ20051114. PMC 1316290. PMID 16107205. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1316290. 
• Mehrle A, Rosenfelder H, Schupp I et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1347501. 
• Coy JF, Velhagen I, Himmele R et al. (1996). "Isolation, differential splicing and protein expression of a DNase on the human X chromosome". Cell Death Differ. 3 (2): 199–206. PMID 17180083.