ATP synthase delta subunit
- ATP synthase delta subunit
Pfam_box
Symbol = OSCP
Name = ATP synthase delta (OSCP) subunit
width =
caption =
Pfam= PF00213
InterPro= IPR000711
SMART=
PROSITE= PDOC00327
SCOP = 1abv
TCDB = 3.A.2
OPM family=
OPM protein=
PDB=PDB3|2a7uB:7-135 PDB3|1abv :7-106 PDB3|2bo5A:37-143
ATP synthase delta subunit is a subunit of bacterial and chloroplast ATPase, or OSCP (oligomycin sensitivity conferral protein) in mitochondrial ATPase (note that in mitochondria there is a different delta subunit, InterPro|IPR001469).
The OSCP/delta subunit appears to be part of the peripheral stalk that holds the F1 complex alpha3beta3 catalytic core stationary against the torque of the rotating central stalk, and links subunit A of the F0 complex with the F1 complex. In mitochondria, the peripheral stalk consists of OSCP, as well as F0 components F6, B and D. In bacteria and chloroplasts the peripheral stalks have different subunit compositions: delta and two copies of F0 component B (bacteria), or delta and F0 components B and B (chloroplasts)[cite journal |author=Walker JE, Runswick MJ, Neuhaus D, Montgomery MG, Carbajo RJ, Kellas FA |title=Structure of the F1-binding domain of the stator of bovine F1Fo-ATPaseand how it binds an alpha-subunit |journal=J. Mol. Biol. |volume=351 |issue=4 |pages=824–838 |year= 2005 |pmid=16045926 |doi=10.1016/j.jmb.2005.06.012] .]Human delta subunit of ATP synthase is coded by gene ATP5O.
References
Further reading
* [1] . Structure and arrangement of the delta subunit in the E. coli ATP synthase (ECF1F0). Wilkens S, Rodgers A, Ogilvie I, Capaldi RA; Biophys Chem 1997;68:95-102. PMID|9468613
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