PAIP2

Poly(A) binding protein interacting protein 2
Rendering of PAIP2 from PDB 1JGN
Available structures PDB 1JGN, 3KUS, 3KUT
Identifiers
Symbols	PAIP2; MGC72018; PAIP2A
External IDs	OMIM: 605604 MGI: 1915119 HomoloGene: 22978 GeneCards: PAIP2 Gene
Gene Ontology Molecular function • protein binding • translation repressor activity Cellular component • cytoplasm Biological process • regulation of translation • negative regulation of translational initiation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51247	67869
Ensembl	ENSG00000120727	ENSMUSG00000037058
UniProt	Q9BPZ3	Q3TJ84
RefSeq (mRNA)	NM_001033112.1	NM_026420.2
RefSeq (protein)	NP_001028284.1	NP_080696.1
Location (UCSC)	Chr 5: 138.68 – 138.71 Mb	Chr 18: 35.76 – 35.78 Mb
PubMed search	[1]	[2]

Polyadenylate-binding protein-interacting protein 2 is a protein that in humans is encoded by the PAIP2 gene.^[1][2][3]

Interactions

PAIP2 has been shown to interact with PABPC1.^[4]

References

1. ^ Khaleghpour K, Svitkin YV, Craig AW, DeMaria CT, Deo RC, Burley SK, Sonenberg N (Feb 2001). "Translational repression by a novel partner of human poly(A) binding protein, Paip2". Mol Cell 7 (1): 205–16. doi:10.1016/S1097-2765(01)00168-X. PMID 11172725. 
2. ^ Berlanga JJ, Baass A, Sonenberg N (Jul 2006). "Regulation of poly(A) binding protein function in translation: Characterization of the Paip2 homolog, Paip2B". RNA 12 (8): 1556–68. doi:10.1261/rna.106506. PMC 1524897. PMID 16804161. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1524897. 
3. ^ "Entrez Gene: PAIP2 poly(A) binding protein interacting protein 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51247. 
4. ^ Khaleghpour, K; Kahvejian A, De Crescenzo G, Roy G, Svitkin Y V, Imataka H, O'Connor-McCourt M, Sonenberg N (Aug. 2001). "Dual Interactions of the Translational Repressor Paip2 with Poly(A) Binding Protein". Mol. Cell. Biol. (United States) 21 (15): 5200–13. doi:10.1128/MCB.21.15.5200-5213.2001. ISSN 0270-7306. PMC 87244. PMID 11438674. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=87244. 

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310934. 
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310948. 
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311072. 
• Kozlov G, Trempe JF, Khaleghpour K, et al. (2001). "Structure and function of the C-terminal PABC domain of human poly(A)-binding protein". Proc. Natl. Acad. Sci. U.S.A. 98 (8): 4409–13. doi:10.1073/pnas.071024998. PMC 31848. PMID 11287632. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=31848. 
• Khaleghpour K, Kahvejian A, De Crescenzo G, et al. (2001). "Dual Interactions of the Translational Repressor Paip2 with Poly(A) Binding Protein". Mol. Cell. Biol. 21 (15): 5200–13. doi:10.1128/MCB.21.15.5200-5213.2001. PMC 87244. PMID 11438674. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=87244. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Gouyon F, Onesto C, Dalet V, et al. (2003). "Fructose modulates GLUT5 mRNA stability in differentiated Caco-2 cells: role of cAMP-signalling pathway and PABP (polyadenylated-binding protein)-interacting protein (Paip) 2". Biochem. J. 375 (Pt 1): 167–74. doi:10.1042/BJ20030661. PMC 1223656. PMID 12820898. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1223656. 
• Onesto C, Berra E, Grépin R, Pagès G (2004). "Poly(A)-binding protein-interacting protein 2, a strong regulator of vascular endothelial growth factor mRNA". J. Biol. Chem. 279 (33): 34217–26. doi:10.1074/jbc.M400219200. PMID 15175342. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528930. 
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1347501. 
• Yoshida M, Yoshida K, Kozlov G, et al. (2006). "Poly(A) binding protein (PABP) homeostasis is mediated by the stability of its inhibitor, Paip2". EMBO J. 25 (9): 1934–44. doi:10.1038/sj.emboj.7601079. PMC 1456944. PMID 16601676. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1456944.