DNASE1L3

Deoxyribonuclease I-like 3
Identifiers
Symbols	DNASE1L3; DHP2; DNAS1L3; LSD
External IDs	OMIM: 602244 MGI: 1314633 HomoloGene: 3630 GeneCards: DNASE1L3 Gene
EC number	3.1.21.-
Gene Ontology Molecular function • DNA binding • deoxyribonuclease activity • calcium ion binding • hydrolase activity • endodeoxyribonuclease activity, producing 5'-phosphomonoesters Cellular component • nucleus Biological process • DNA metabolic process • DNA catabolic process • apoptosis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1776	13421
Ensembl	ENSG00000163687	ENSMUSG00000025279
UniProt	Q13609	Q3T9W0
RefSeq (mRNA)	NM_004944	NM_007870.3
RefSeq (protein)	NP_004935	NP_031896.3
Location (UCSC)	Chr 3: 58.18 – 58.2 Mb	Chr 14: 8.8 – 8.83 Mb
PubMed search	[1]	[2]

Deoxyribonuclease gamma is an enzyme that in humans is encoded by the DNASE1L3 gene.^[1][2][3][4] This gene encodes a member of the DNase family. The protein hydrolyzes DNA, is not inhibited by actin, and mediates the breakdown of DNA during apoptosis. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.^[4]

References

1. ^ Rodriguez AM, Rodin D, Nomura H, Morton CC, Weremowicz S, Schneider MC (Sep 1997). "Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I". Genomics 42 (3): 507–13. doi:10.1006/geno.1997.4748. PMID 9205125. 
2. ^ Baron WF, Pan CQ, Spencer SA, Ryan AM, Lazarus RA, Baker KP (Oct 1998). "Cloning and characterization of an actin-resistant DNase I-like endonuclease secreted by macrophages". Gene 215 (2): 291–301. doi:10.1016/S0378-1119(98)00281-9. PMID 9714828. 
3. ^ Shiokawa D, Hirai M, Tanuma S (Dec 2003). "cDNA cloning of human DNase gamma: chromosomal localization of its gene and enzymatic properties of recombinant protein". Apoptosis 3 (2): 89–95. doi:10.1023/A:1009692807692. PMID 14646506. 
4. ^ ^{a b} "Entrez Gene: DNASE1L3 deoxyribonuclease I-like 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1776. 

Further reading

• Tanuma S, Shiokawa D (1994). "Multiple forms of nuclear deoxyribonuclease in rat thymocytes.". Biochem. Biophys. Res. Commun. 203 (2): 789–97. doi:10.1006/bbrc.1994.2252. PMID 8093058. 
• Zeng Z, Parmelee D, Hyaw H, et al. (1997). "Cloning and characterization of a novel human DNase.". Biochem. Biophys. Res. Commun. 231 (2): 499–504. doi:10.1006/bbrc.1996.5923. PMID 9070308. 
• Shiokawa D, Tanuma S (2001). "Characterization of human DNase I family endonucleases and activation of DNase gamma during apoptosis.". Biochemistry 40 (1): 143–52. doi:10.1021/bi001041a. PMID 11141064. 
• Wilber A, Lu M, Schneider MC (2003). "Deoxyribonuclease I-like III is an inducible macrophage barrier to liposomal transfection.". Mol. Ther. 6 (1): 35–42. doi:10.1006/mthe.2002.0625. PMID 12095301. 
• Boulares AH, Zoltoski AJ, Sherif ZA, et al. (2002). "The Poly(ADP-ribose) polymerase-1-regulated endonuclease DNAS1L3 is required for etoposide-induced internucleosomal DNA fragmentation and increases etoposide cytotoxicity in transfected osteosarcoma cells.". Cancer Res. 62 (15): 4439–44. PMID 12154052. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Shiokawa D, Shika Y, Tanuma S (2003). "Identification of two functional nuclear localization signals in DNase gamma and their roles in its apoptotic DNase activity.". Biochem. J. 376 (Pt 2): 377–81. doi:10.1042/BJ20030820. PMC 1223774. PMID 12943533. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1223774. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Boulares AH, Ren T (2004). "Mechanism of acetaminophen-induced apoptosis in cultured cells: roles of caspase-3, DNA fragmentation factor, and the Ca2+ and Mg2+ endonuclease DNAS1L3.". Basic Clin. Pharmacol. Toxicol. 94 (1): 19–29. doi:10.1111/j.1742-7843.2004.pto_940105.x. PMID 14725611. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Okamoto M, Okamoto N, Yashiro H, et al. (2005). "Involvement of DNase gamma in the resected double-strand DNA breaks in immunoglobulin genes.". Biochem. Biophys. Res. Commun. 327 (1): 76–83. doi:10.1016/j.bbrc.2004.11.142. PMID 15629432. 
• Boulares H, Zoltoski A, Kandan S, et al. (2006). "Correlation between decreased sensitivity of the Daudi lymphoma cells to VP-16-induced apoptosis and deficiency in DNAS1L3 expression.". Biochem. Biophys. Res. Commun. 341 (2): 653–62. doi:10.1016/j.bbrc.2006.01.014. PMID 16427601.