PACSIN2

Protein kinase C and casein kinase substrate in neurons 2
Rendering based on PDB 3ABH.
Available structures PDB 3ABH, 3ACO, 3HAJ
Identifiers
Symbols	PACSIN2; SDPII
External IDs	OMIM: 604960 MGI: 1345153 HomoloGene: 21414 GeneCards: PACSIN2 Gene
Gene Ontology Molecular function • transporter activity • protein binding • cytoskeletal protein binding Cellular component • cytoplasm • cytosol • cytoplasmic membrane-bounded vesicle Biological process • transport • actin cytoskeleton organization • negative regulation of endocytosis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11252	23970
Ensembl	ENSG00000100266	ENSMUSG00000016664
UniProt	Q9UNF0	Q3TDA7
RefSeq (mRNA)	NM_001184970.1	NM_011862
RefSeq (protein)	NP_001171899.1	NP_035992
Location (UCSC)	Chr 22: 43.23 – 43.41 Mb	Chr 15: 83.21 – 83.3 Mb
PubMed search	[1]	[2]

Protein kinase C and casein kinase substrate in neurons protein 2 is an enzyme that in humans is encoded by the PACSIN2 gene.^[1][2][3]

Interactions

PACSIN2 has been shown to interact with PACSIN1,^[2][4] PACSIN3^[2] and Fas ligand.^[5]

References

1. ^ Ritter B, Modregger J, Paulsson M, Plomann M (Aug 1999). "PACSIN 2, a novel member of the PACSIN family of cytoplasmic adapter proteins". FEBS Lett 454 (3): 356–62. doi:10.1016/S0014-5793(99)00830-3. PMID 10431838. 
2. ^ ^{a b c} Modregger J, Ritter B, Witter B, Paulsson M, Plomann M (Jan 2001). "All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis". J Cell Sci 113 Pt 24: 4511–21. PMID 11082044. 
3. ^ "Entrez Gene: PACSIN2 protein kinase C and casein kinase substrate in neurons 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11252. 
4. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
5. ^ Ghadimi, Markus Philipp; Sanzenbacher Ralf, Thiede Bernd, Wenzel Jennifer, Jing Qian, Plomann Markus, Borkhardt Arndt, Kabelitz Dieter, Janssen Ottmar (May. 2002). "Identification of interaction partners of the cytosolic polyproline region of CD95 ligand (CD178)". FEBS Lett. (Netherlands) 519 (1–3): 50–8. doi:10.1016/S0014-5793(02)02709-6. ISSN 0014-5793. PMID 12023017. 

Further reading

• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474. 
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139146. 
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. 
• Sumoy L, Pluvinet R, Andreu N, et al. (2001). "PACSIN 3 is a novel SH3 domain cytoplasmic adapter protein of the pacsin-syndapin-FAP52 gene family". Gene 262 (1–2): 199–205. doi:10.1016/S0378-1119(00)00531-X. PMID 11179684. 
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311072. 
• Ghadimi MP, Sanzenbacher R, Thiede B, et al. (2002). "Identification of interaction partners of the cytosolic polyproline region of CD95 ligand (CD178)". FEBS Lett. 519 (1–3): 50–8. doi:10.1016/S0014-5793(02)02709-6. PMID 12023017. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=545604. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Kessels MM, Dong J, Leibig W, et al. (2006). "Complexes of syndapin II with dynamin II promote vesicle formation at the trans-Golgi network". J. Cell. Sci. 119 (Pt 8): 1504–16. doi:10.1242/jcs.02877. PMID 16551695. 
• Cuajungco MP, Grimm C, Oshima K, et al. (2006). "PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4". J. Biol. Chem. 281 (27): 18753–62. doi:10.1074/jbc.M602452200. PMID 16627472. 
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.