Adaptor-related protein complex 1, sigma 2 subunit, also known as AP1S2, is a human gene.cite web | title = Entrez Gene: AP1S2 adaptor-related protein complex 1, sigma 2 subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8905| accessdate = ]

section_title =
summary_text = Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as the small subunit of this complex and is a member of the adaptin protein family. Transcript variants utilizing alternative polyadenylation signals exist for this gene.cite web | title = Entrez Gene: AP1S2 adaptor-related protein complex 1, sigma 2 subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8905| accessdate = ]


Further reading

citations =
*cite journal | author=Kirchhausen T |title=Clathrin. |journal=Annu. Rev. Biochem. |volume=69 |issue= |pages= 699–727 |year= 2000 |pmid= 10966473 |doi= 10.1146/annurev.biochem.69.1.699
*cite journal | author=Geyer M, Fackler OT, Peterlin BM |title=Structure--function relationships in HIV-1 Nef. |journal=EMBO Rep. |volume=2 |issue= 7 |pages= 580–5 |year= 2001 |pmid= 11463741 |doi= 10.1093/embo-reports/kve141
*cite journal | author=Bénichou S, Benmerah A |title= [The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway] |journal=Med Sci (Paris) |volume=19 |issue= 1 |pages= 100–6 |year= 2003 |pmid= 12836198 |doi=
*cite journal | author=Kirchhausen T, Davis AC, Frucht S, "et al." |title=AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast. |journal=J. Biol. Chem. |volume=266 |issue= 17 |pages= 11153–7 |year= 1991 |pmid= 2040623 |doi=
*cite journal | author=Takatsu H, Sakurai M, Shin HW, "et al." |title=Identification and characterization of novel clathrin adaptor-related proteins. |journal=J. Biol. Chem. |volume=273 |issue= 38 |pages= 24693–700 |year= 1998 |pmid= 9733768 |doi=
*cite journal | author=Craig HM, Pandori MW, Guatelli JC |title=Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 19 |pages= 11229–34 |year= 1998 |pmid= 9736718 |doi=
*cite journal | author=Bresnahan PA, Yonemoto W, Ferrell S, "et al." |title=A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor. |journal=Curr. Biol. |volume=8 |issue= 22 |pages= 1235–8 |year= 1999 |pmid= 9811606 |doi=
*cite journal | author=Greenberg M, DeTulleo L, Rapoport I, "et al." |title=A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4. |journal=Curr. Biol. |volume=8 |issue= 22 |pages= 1239–42 |year= 1999 |pmid= 9811611 |doi=
*cite journal | author=Berlioz-Torrent C, Shacklett BL, Erdtmann L, "et al." |title=Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins. |journal=J. Virol. |volume=73 |issue= 2 |pages= 1350–61 |year= 1999 |pmid= 9882340 |doi=
*cite journal | author=Wyss S, Berlioz-Torrent C, Boge M, "et al." |title=The highly conserved C-terminal dileucine motif in the cytosolic domain of the human immunodeficiency virus type 1 envelope glycoprotein is critical for its association with the AP-1 clathrin adaptor [correction of adapter] . |journal=J. Virol. |volume=75 |issue= 6 |pages= 2982–92 |year= 2001 |pmid= 11222723 |doi= 10.1128/JVI.75.6.2982-2992.2001
*cite journal | author=Doray B, Ghosh P, Griffith J, "et al." |title=Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network. |journal=Science |volume=297 |issue= 5587 |pages= 1700–3 |year= 2002 |pmid= 12215646 |doi= 10.1126/science.1075327
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Janvier K, Craig H, Hitchin D, "et al." |title=HIV-1 Nef stabilizes the association of adaptor protein complexes with membranes. |journal=J. Biol. Chem. |volume=278 |issue= 10 |pages= 8725–32 |year= 2003 |pmid= 12486136 |doi= 10.1074/jbc.M210115200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Coleman SH, Van Damme N, Day JR, "et al." |title=Leucine-specific, functional interactions between human immunodeficiency virus type 1 Nef and adaptor protein complexes. |journal=J. Virol. |volume=79 |issue= 4 |pages= 2066–78 |year= 2005 |pmid= 15681409 |doi= 10.1128/JVI.79.4.2066-2078.2005
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Coleman SH, Hitchin D, Noviello CM, Guatelli JC |title=HIV-1 Nef stabilizes AP-1 on membranes without inducing ARF1-independent de novo attachment. |journal=Virology |volume=345 |issue= 1 |pages= 148–55 |year= 2006 |pmid= 16253302 |doi= 10.1016/j.virol.2005.09.045

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