NUTF2

Nuclear transport factor 2
PDB rendering based on 1a2k.
Available structures PDB 1a2k, 1ar0, 1ask, 1gy5, 1gy6, 1jb2, 1jb4, 1jb5, 1oun, 1qma, 1u5o
Identifiers
Symbols	NUTF2; NTF2; PP15
External IDs	OMIM: 605813 MGI: 1915301 HomoloGene: 110745 GeneCards: NUTF2 Gene
Gene Ontology Molecular function • transporter activity • protein binding Cellular component • intracellular • nuclear pore • cytoplasm • cytosol Biological process • transport • protein transport Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10204	68051
Ensembl	ENSG00000102898	n/a
UniProt	P61970	n/a
RefSeq (mRNA)	NM_005796	NM_026532.3
RefSeq (protein)	NP_005787	NP_080808.1
Location (UCSC)	Chr 16: 67.88 – 67.91 Mb	n/a
PubMed search	[1]	[2]

Nuclear transport factor 2 is a protein that in humans is encoded by the NUTF2 gene.^[1][2][3]

The protein encoded by this gene is a cytosolic factor that facilitates protein transport into the nucleus. It interacts with the nuclear pore complex glycoprotein p62. This encoded protein acts at a relative late stage of nuclear protein import, subsequent to the initial docking of nuclear import ligand at the nuclear envelope. It is thought to be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import.^[3]

Interactions

NUTF2 has been shown to interact with Nucleoporin 62^[1][4] and Ran (biology).^[5][6]

References

1. ^ ^{a b} Paschal BM, Gerace L (Jun 1995). "Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62". J Cell Biol 129 (4): 925–937. doi:10.1083/jcb.129.4.925. PMC 2120498. PMID 7744965. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2120498. 
2. ^ Grundmann U, Nerlich C, Rein T, Lottspeich F, Kupper HA (Jul 1988). "Isolation of cDNA coding for the placental protein 15 (PP15)". Nucleic Acids Res 16 (10): 4721–4721. doi:10.1093/nar/16.10.4721. PMC 336660. PMID 3380696. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=336660. 
3. ^ ^{a b} "Entrez Gene: NUTF2 nuclear transport factor 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10204. 
4. ^ Hu, T; Guan T, Gerace L (Aug. 1996). "Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins". J. Cell Biol. (UNITED STATES) 134 (3): 589–601. doi:10.1083/jcb.134.3.589. ISSN 0021-9525. PMC 2120945. PMID 8707840. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2120945. 
5. ^ Cushman, Ian; Bowman Brian R, Sowa Mathew E, Lichtarge Olivier, Quiocho Florante A, Moore Mary Shannon (Nov. 2004). "Computational and biochemical identification of a nuclear pore complex binding site on the nuclear transport carrier NTF2". J. Mol. Biol. (England) 344 (2): 303–310. doi:10.1016/j.jmb.2004.09.043. ISSN 0022-2836. PMID 15522285. 
6. ^ Stewart, M; Kent H M, McCoy A J (Apr. 1998). "Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran". J. Mol. Biol. (ENGLAND) 277 (3): 635–646. doi:10.1006/jmbi.1997.1602. ISSN 0022-2836. PMID 9533885. 

Further reading

• Bukrinsky MI, Haffar OK (1998). "HIV-1 nuclear import: matrix protein is back on center stage, this time together with Vpr". Mol. Med. 4 (3): 138–43. PMC 2230352. PMID 9562972. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2230352. 
• Stewart M (2001). "Insights into the molecular mechanism of nuclear trafficking using nuclear transport factor 2 (NTF2)". Cell Struct. Funct. 25 (4): 217–225. doi:10.1247/csf.25.217. PMID 11129791. 
• Bohn H, Johannsen R, Kraus W (1981). "[New placental protein (PP15) with immunosuppressive properties (author's transl)]". Arch. Gynecol. 230 (2): 167–72. PMID 7458421. 
• Hu T, Guan T, Gerace L (1996). "Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins". J. Cell Biol. 134 (3): 589–601. doi:10.1083/jcb.134.3.589. PMC 2120945. PMID 8707840. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2120945. 
• Bullock TL, Clarkson WD, Kent HM, Stewart M (1996). "The 1.6 angstroms resolution crystal structure of nuclear transport factor 2 (NTF2)". J. Mol. Biol. 260 (3): 422–431. doi:10.1006/jmbi.1996.0411. PMID 8757804. 
• Clarkson WD, Corbett AH, Paschal BM et al. (1997). "Nuclear protein import is decreased by engineered mutants of nuclear transport factor 2 (NTF2) that do not bind GDP-Ran". J. Mol. Biol. 272 (5): 716–730. doi:10.1006/jmbi.1997.1255. PMID 9368653. 
• Stewart M, Kent HM, McCoy AJ (1998). "Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran". J. Mol. Biol. 277 (3): 635–646. doi:10.1006/jmbi.1997.1602. PMID 9533885. 
• Ribbeck K, Lipowsky G, Kent HM et al. (1999). "NTF2 mediates nuclear import of Ran". EMBO J. 17 (22): 6587–6598. doi:10.1093/emboj/17.22.6587. PMC 1171005. PMID 9822603. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171005. 
• Steggerda SM, Black BE, Paschal BM (2000). "Monoclonal antibodies to NTF2 inhibit nuclear protein import by preventing nuclear translocation of the GTPase Ran". Mol. Biol. Cell 11 (2): 703–19. PMC 14804. PMID 10679025. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=14804. 
• Freire J, Covelo G, Sarandeses C et al. (2001). "Identification of nuclear-import and cell-cycle regulatory proteins that bind to prothymosin alpha". Biochem. Cell Biol. 79 (2): 123–131. doi:10.1139/bcb-79-2-123. PMID 11310559. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Cushman I, Bowman BR, Sowa ME et al. (2004). "Computational and biochemical identification of a nuclear pore complex binding site on the nuclear transport carrier NTF2". J. Mol. Biol. 344 (2): 303–310. doi:10.1016/j.jmb.2004.09.043. PMID 15522285. 
• Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514. 

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