NSFL1 (p97) cofactor (p47)

PDB rendering based on 1i42.
Symbols NSFL1C; FLJ46889; MGC3347; P47; UBX1; UBXD10; UBXN2C; dJ776F14.1
External IDs OMIM606610 MGI3042273 HomoloGene41114 GeneCards: NSFL1C Gene
RNA expression pattern
PBB GE NSFL1C 217830 s at tn.png
PBB GE NSFL1C 220248 x at tn.png
PBB GE NSFL1C 217831 s at tn.png
More reference expression data
Species Human Mouse
Entrez 55968 386649
Ensembl ENSG00000088833 ENSMUSG00000027455
UniProt Q9UNZ2 Q3KQQ1
RefSeq (mRNA) NM_001206736.1 NM_198326.2
RefSeq (protein) NP_001193665.1 NP_938085.1
Location (UCSC) Chr 20:
1.42 – 1.45 Mb
Chr 2:
151.32 – 151.34 Mb
PubMed search [1] [2]

NSFL1 cofactor p47 is a protein that in humans is encoded by the NSFL1C gene.[1][2]

N-ethylmaleimide-sensitive factor (NSF) and valosin-containing protein (p97) are two ATPases known to be involved in transport vesicle/target membrane fusion and fusions between membrane compartments. A trimer of the protein encoded by this gene binds a hexamer of cytosolic p97 and is required for p97-mediated regrowth of Golgi cisternae from mitotic Golgi fragments. Multiple transcript variants encoding several different isoforms have been found for this gene.[2]


NSFL1C has been shown to interact with Valosin-containing protein.[3]


Further reading

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