RAC3 (gene)

Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3), also known as RAC3, is a human gene.cite web | title = Entrez Gene: RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5881| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases.cite web | title = Entrez Gene: RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5881| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Didsbury J, Weber RF, Bokoch GM, "et al." |title=rac, a novel ras-related family of proteins that are botulinum toxin substrates. |journal=J. Biol. Chem. |volume=264 |issue= 28 |pages= 16378–82 |year= 1989 |pmid= 2674130 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Haataja L, Groffen J, Heisterkamp N |title=Characterization of RAC3, a novel member of the Rho family. |journal=J. Biol. Chem. |volume=272 |issue= 33 |pages= 20384–8 |year= 1997 |pmid= 9252344 |doi=
*cite journal | author=Courjal F, Chuchana P, Theillet C, Fort P |title=Structure and chromosomal assignment to 22q12 and 17qter of the ras-related Rac2 and Rac3 human genes. |journal=Genomics |volume=44 |issue= 2 |pages= 242–6 |year= 1997 |pmid= 9299243 |doi= 10.1006/geno.1997.4871
*cite journal | author=Mira JP, Benard V, Groffen J, "et al." |title=Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 1 |pages= 185–9 |year= 2000 |pmid= 10618392 |doi=
*cite journal | author=Soutoglou E, Papafotiou G, Katrakili N, Talianidis I |title=Transcriptional activation by hepatocyte nuclear factor-1 requires synergism between multiple coactivator proteins. |journal=J. Biol. Chem. |volume=275 |issue= 17 |pages= 12515–20 |year= 2000 |pmid= 10777539 |doi=
*cite journal | author=Morris CM, Haataja L, McDonald M, "et al." |title=The small GTPase RAC3 gene is located within chromosome band 17q25.3 outside and telomeric of a region commonly deleted in breast and ovarian tumours. |journal=Cytogenet. Cell Genet. |volume=89 |issue= 1-2 |pages= 18–23 |year= 2000 |pmid= 10894930 |doi=
*cite journal | author=Gnanapragasam VJ, Leung HY, Pulimood AS, "et al." |title=Expression of RAC 3, a steroid hormone receptor co-activator in prostate cancer. |journal=Br. J. Cancer |volume=85 |issue= 12 |pages= 1928–36 |year= 2002 |pmid= 11747336 |doi= 10.1054/bjoc.2001.2179
*cite journal | author=Haataja L, Kaartinen V, Groffen J, Heisterkamp N |title=The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 8321–8 |year= 2002 |pmid= 11756406 |doi= 10.1074/jbc.M105363200
*cite journal | author=De Langhe S, Haataja L, Senadheera D, "et al." |title=Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain. |journal=Int. J. Mol. Med. |volume=9 |issue= 5 |pages= 451–9 |year= 2002 |pmid= 11956649 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Zhang A, Yeung PL, Li CW, "et al." |title=Identification of a novel family of ankyrin repeats containing cofactors for p160 nuclear receptor coactivators. |journal=J. Biol. Chem. |volume=279 |issue= 32 |pages= 33799–805 |year= 2004 |pmid= 15184363 |doi= 10.1074/jbc.M403997200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Hwang SL, Chang JH, Cheng TS, "et al." |title=Expression of Rac3 in human brain tumors. |journal=Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia |volume=12 |issue= 5 |pages= 571–4 |year= 2006 |pmid= 15993075 |doi= 10.1016/j.jocn.2004.08.013
*cite journal | author=Chan AY, Coniglio SJ, Chuang YY, "et al." |title=Roles of the Rac1 and Rac3 GTPases in human tumor cell invasion. |journal=Oncogene |volume=24 |issue= 53 |pages= 7821–9 |year= 2005 |pmid= 16027728 |doi= 10.1038/sj.onc.1208909
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Baugher PJ, Krishnamoorthy L, Price JE, Dharmawardhane SF |title=Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells. |journal=Breast Cancer Res. |volume=7 |issue= 6 |pages= R965–74 |year= 2006 |pmid= 16280046 |doi= 10.1186/bcr1329
*cite journal | author=Watabe-Uchida M, John KA, Janas JA, "et al." |title=The Rac activator DOCK7 regulates neuronal polarity through local phosphorylation of stathmin/Op18. |journal=Neuron |volume=51 |issue= 6 |pages= 727–39 |year= 2006 |pmid= 16982419 |doi= 10.1016/j.neuron.2006.07.020
*cite journal | author=Hajdo-Milasinović A, Ellenbroek SI, van Es S, "et al." |title=Rac1 and Rac3 have opposing functions in cell adhesion and differentiation of neuronal cells. |journal=J. Cell. Sci. |volume=120 |issue= Pt 4 |pages= 555–66 |year= 2007 |pmid= 17244648 |doi= 10.1242/jcs.03364

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