- EPHA1
EPH receptor A1, also known as EPHA1, is a human
gene .cite web | title = Entrez Gene: EPHA1 EPH receptor A1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2041| accessdate = ]PBB_Summary
section_title =
summary_text = This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis.cite web | title = Entrez Gene: EPHA1 EPH receptor A1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2041| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Flanagan JG, Vanderhaeghen P |title=The ephrins and Eph receptors in neural development. |journal=Annu. Rev. Neurosci. |volume=21 |issue= |pages= 309–45 |year= 1998 |pmid= 9530499 |doi= 10.1146/annurev.neuro.21.1.309
*cite journal | author=Zhou R |title=The Eph family receptors and ligands. |journal=Pharmacol. Ther. |volume=77 |issue= 3 |pages= 151–81 |year= 1998 |pmid= 9576626 |doi=
*cite journal | author=Holder N, Klein R |title=Eph receptors and ephrins: effectors of morphogenesis. |journal=Development |volume=126 |issue= 10 |pages= 2033–44 |year= 1999 |pmid= 10207129 |doi=
*cite journal | author=Wilkinson DG |title=Eph receptors and ephrins: regulators of guidance and assembly. |journal=Int. Rev. Cytol. |volume=196 |issue= |pages= 177–244 |year= 2000 |pmid= 10730216 |doi=
*cite journal | author=Xu Q, Mellitzer G, Wilkinson DG |title=Roles of Eph receptors and ephrins in segmental patterning. |journal=Philos. Trans. R. Soc. Lond., B, Biol. Sci. |volume=355 |issue= 1399 |pages= 993–1002 |year= 2001 |pmid= 11128993 |doi= 10.1098/rstb.2000.0635
*cite journal | author=Wilkinson DG |title=Multiple roles of EPH receptors and ephrins in neural development. |journal=Nat. Rev. Neurosci. |volume=2 |issue= 3 |pages= 155–64 |year= 2001 |pmid= 11256076 |doi=
*cite journal | author=Hirai H, Maru Y, Hagiwara K, "et al." |title=A novel putative tyrosine kinase receptor encoded by the eph gene. |journal=Science |volume=238 |issue= 4834 |pages= 1717–20 |year= 1988 |pmid= 2825356 |doi=
*cite journal | author=Gale NW, Holland SJ, Valenzuela DM, "et al." |title=Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. |journal=Neuron |volume=17 |issue= 1 |pages= 9–19 |year= 1996 |pmid= 8755474 |doi=
*cite journal | author= |title=Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. |journal=Cell |volume=90 |issue= 3 |pages= 403–4 |year= 1997 |pmid= 9267020 |doi=
*cite journal | author=Owshalimpur D, Kelley MJ |title=Genomic structure of the EPHA1 receptor tyrosine kinase gene. |journal=Mol. Cell. Probes |volume=13 |issue= 3 |pages= 169–73 |year= 1999 |pmid= 10369740 |doi= 10.1006/mcpr.1999.0228
*cite journal | author=Kalo MS, Pasquale EB |title=Signal transfer by eph receptors |journal= |volume=298 |issue= 1 |pages= 1–9 |year= |pmid= 10502115 |doi=
*cite journal | author=Coulthard MG, Lickliter JD, Subanesan N, "et al." |title=Characterization of the Epha1 receptor tyrosine kinase: expression in epithelial tissues. |journal=Growth Factors |volume=18 |issue= 4 |pages= 303–17 |year= 2002 |pmid= 11519828 |doi=
*cite journal | author=Hillier LW, Fulton RS, Fulton LA, "et al." |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782
*cite journal | author=Brandenberger R, Wei H, Zhang S, "et al." |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971PBB_Controls
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